Evidence map›Paper›PMID 31391596›Full record

ArticleNature biomedical engineering2019

Use of a supramolecular polymeric hydrogel as an effective post-operative pericardial adhesion barrier.

Lyndsay M Stapleton, Amanda N Steele, Hanjay Wang, Hector Lopez Hernandez, Anthony C Yu, Michael J Paulsen, Anton A A Smith, Gillie A Roth, Akshara D Thakore, Haley J Lucian and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
25.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 233 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Lyndsay M StapletonDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Amanda N SteeleDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Hector Lopez HernandezDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6018-9587
Anthony C YuDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA.
Michael J PaulsenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Anton A A SmithDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA.
Gillie A RothDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3451-3694
Akshara D ThakoreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Haley J LucianDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Kailey P TotherowDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Sam W BakerDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Yuko TadaDepartment of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Justin M FarryDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Anahita EskandariDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Camille E HironakaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Kevin J JaatinenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Kiah M WilliamsDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0837-2760
Hunter BergamascoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Clifton MarschelDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Blaine ChadwickDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Frederick GradyDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Michael MaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Eric A AppelDepartment of Bioengineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0002-2301-7126
Y Joseph WooDepartment of Bioengineering, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.ORCID http://orcid.org/0000-0002-2506-492X
Stanford University · USStanford Medicine · US

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
NHLBI NIH HHS R01 HL089315U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL089315-01
6 · The paper itself

Abstract

Post-operative adhesions form as a result of normal wound healing processes following any type of surgery. In cardiac surgery, pericardial adhesions are particularly problematic during reoperations, as surgeons must release the adhesions from the surface of the heart before the intended procedure can begin, thereby substantially lengthening operation times and introducing risks of haemorrhage and injury to the heart and lungs during sternal re-entry and cardiac dissection. Here we show that a dynamically crosslinked supramolecular polymer-nanoparticle hydrogel, with viscoelastic and flow properties that enable spraying onto tissue as well as robust tissue adherence and local retention in vivo for two weeks, reduces the formation of pericardial adhesions. In a rat model of severe pericardial adhesions, the hydrogel markedly reduced the severity of the adhesions, whereas commercial adhesion barriers (including Seprafilm and Interceed) did not. The hydrogels also reduced the severity of cardiac adhesions (relative to untreated animals) in a clinically relevant cardiopulmonary-bypass model in sheep. This viscoelastic supramolecular polymeric hydrogel represents a promising clinical solution for the prevention of post-operative pericardial adhesions.

Indexed as

Tissue AdhesionsAnimalsCardiac Surgical ProceduresCellulose, OxidizedHyaluronic AcidHydrogelsMaleModels, AnimalNanoparticlesPericardiumPolymersRatsSheepCellulose, OxidizedHyaluronic AcidHydrogelsINTERCEEDPolymersSeprafilm

Identifiers

PMID31391596
PMCPMC13371111
OpenAlexW2966348083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.