ArticleNature2019
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.
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Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 435 papers.
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435citing papers in PubMed
31.7field-weighted citation impact, top 1% of its field
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Who cites it
435 citing papers in PubMed, 702 citations in OpenAlex.
- How do low-complexity domain interactions control transcription?Biochemical Society transactions · 2026Review
- Tracking cellular biomolecular condensate dynamics under proteostatic stress with middle-down phosphoproteomics.bioRxiv : the preprint server for biology · 2026Article
- Emergent 3D genome reorganization and graded gene control from the stepwise assembly of transcriptional condensates.Cell reports · 2026Article
- Phase Separation of SF3B1 Serves as a Critical Post-Transcriptional Regulator During Early Mouse Embryogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- hnRNPK condensates facilitate enhancer-promoter looping and RNA polymerase II recruitment.Nature genetics · 2026Article
- ATRX Condensates as Candidate Organizers of Enhancer-Centered Nuclear Microenvironments in Neural Progenitors: A Hypothesis for Enhancer-Associated ATRX Function in Neural Progenitors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Aberrant Phase Separation of Endothelial MAML1 Causes Congenital Heart Disease by Suppressing Notch Activity.Circulation · 2026Article
- Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Opposing roles of serine and charge in IDR condensate miscibility.Nature chemical biology · 2026Article
- Transcription initiation drives dosage compensation establishment and maintenance in maleScience advances · 2026Article
- Active RNA synthesis patterns nuclear condensates.Cell systems · 2026Article
- Hierarchical Nuclear Architecture in Pre-mRNA Splicing: From IDRs to Speckles and Meshworks.International journal of molecular sciences · 2026Review
- Mediator subunit MED4 enforces metastatic dormancy in breast cancer.Nature cell biology · 2026Article
- Kaposi's Sarcoma-associated herpesvirus uses a novel protein fold to hijack RNA Polymerase II for viral late gene transcription.bioRxiv : the preprint server for biology · 2026Article
- Protocol for cell cycle-resolved high-content imaging of transcription condensate dynamics in human cells.STAR protocols · 2026Article
- NUDT21 Drives T-Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- IDRs lead the way: Cooperativity between intrinsically disordered regions and structured interaction domains drives enrichment in transcription condensates.bioRxiv : the preprint server for biology · 2026Article
- Transcription condensates are promoter hubs that enhance transcriptional bursts.bioRxiv : the preprint server for biology · 2026Article
- Review
- YTHDC1 recognizes METTL16-dependent mProceedings of the National Academy of Sciences of the United States of America · 2026Article
375 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 1 country.
Yang Eric Guo *Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
John C Manteiga *Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Jonathan E HenningerWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Benjamin R SabariWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Alessandra Dall'AgneseWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Nancy M HannettWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Jan-Hendrik SpilleDepartment of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lena K AfeyanWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Alicia V ZamudioWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Krishna ShrinivasDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Brian J AbrahamWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Ann BoijaWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Tim-Michael DeckerDepartment of Biochemistry, University of Colorado, Boulder, CO, USA.
Jenna K RimelDepartment of Biochemistry, University of Colorado, Boulder, CO, USA.
Charli B FantDepartment of Biochemistry, University of Colorado, Boulder, CO, USA.
Tong Ihn LeeWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Ibrahim I CisseDepartment of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Phillip A SharpDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Dylan J TaatjesDepartment of Biochemistry, University of Colorado, Boulder, CO, USA.
Richard A YoungWhitehead Institute for Biomedical Research, Cambridge, MA, USA. young@wi.mit.edu.
Whitehead Institute for Biomedical Research · USMassachusetts Institute of Technology · USUniversity of Colorado Boulder · USSt. Jude Children's Research Hospital · US
Funding
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8MREGULATION OF MRNA PROCESSINGR01GM034277 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SHARP, PHILLIP A · 1985 to 2021
$8.0MTRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9MTranscriptional regulatory networks in living cellsR01GM123511 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI YOUNG, RICHARD · 2017 to 2020
$3.6MTFIIH and Transcription RegulationR01GM110064 · NIGMS · UNIVERSITY OF COLORADO · PI RANISH, JEFFREY A, TAATJES, DYLAN J · 2016 to 2019
$2.2MMediator Kinases and Transcription RegulationR01GM117370 · NIGMS · UNIVERSITY OF COLORADO · PI TAATJES, DYLAN J · 2016 to 2019
$1.5MNIGMS NIH HHS R01 GM034277NIGMS NIH HHS R01 GM110064NIGMS NIH HHS R01 GM117370NIGMS NIH HHS R01 GM123511NIGMS NIH HHS T32 GM007287NIGMS NIH HHS T32 GM008759
Abstract
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex
Indexed as
RNA SplicingTranscription, GeneticAnimalsCell LineEnhancer Elements, GeneticGene Expression RegulationHumansMediator ComplexMicePhosphorylationProtein DomainsRNA Polymerase IIRNA Splicing FactorsMediator ComplexRNA Polymerase IIRNA Splicing Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.