ArticleScientific reports2019
CRISPR/Cas9-mediated mutagenesis of CAROTENOID CLEAVAGE DIOXYGENASE 8 in tomato provides resistance against the parasitic weed Phelipanche aegyptiaca.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome editing for vegetable crop improvement: Challenges and future prospects.Frontiers in genetics · 2022Pooled it
- Synergistic Effects of Amino Acids andPlants (Basel, Switzerland) · 2026Article
- The role of isoprenoids in the chemical interaction between plants and other organisms in their rhizosphere.aBIOTECH · 2025Review
- Transcription factors SlMYB41, SlMYB92, and SlWRKY71 regulate gene expression in the tomato exodermis.Journal of experimental botany · 2025Article
- Broomrapes in Major Mediterranean Crops: From Management Strategies to Novel Approaches for Next-Generation Control.Biotech (Basel (Switzerland)) · 2025Review
- Review
- Developing Striga resistance in sorghum by modulating host cues through CRISPR/Cas9 gene editing.Plant cell reports · 2025Article
- Manipulation of a strigolactone transporter in tomato confers resistance to the parasitic weed broomrape.Innovation (Cambridge (Mass.)) · 2025Article
- Advancing vegetable genetics with gene editing: a pathway to food security and nutritional resilience in climate-shifted environments.Functional & integrative genomics · 2025Review
- Regulation and function of a polarly localized lignin barrier in the exodermis.Nature plants · 2025Article
- Genome-wide identification and comparative analysis of strigolactone biosynthetic genes in major solanaceous crops.PloS one · 2025Article
- Genomics in plant pathogen identification and control.Frontiers in plant science · 2025Review
- Transcriptomic Approach for Investigation ofCurrent issues in molecular biology · 2024Article
- Revolutionizing Tomato Cultivation: CRISPR/Cas9 Mediated Biotic Stress Resistance.Plants (Basel, Switzerland) · 2024Review
- Unleashing plant synthetic capacity: navigating regulatory mechanisms for enhanced bioproduction and secondary metabolite discovery.Current opinion in biotechnology · 2024Review
- Tomato Mutants Reveal Root and Shoot Strigolactone Involvement in Branching and Broomrape Resistance.Plants (Basel, Switzerland) · 2024Article
- Crop bioengineering via gene editing: reshaping the future of agriculture.Plant cell reports · 2024Review
- A suberized exodermis is required for tomato drought tolerance.Nature plants · 2024Article
- The Complex Interplay between Arbuscular Mycorrhizal Fungi and Strigolactone: Mechanisms, Sinergies, Applications and Future Directions.International journal of molecular sciences · 2023Review
- Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Broomrapes (Phelipanche aegyptiaca and Orobanche spp.) are obligate plant parasites that cause extreme damage to crop plants. The parasite seeds have strict requirements for germination, involving preconditioning and exposure to specific chemicals strigolactones [SLs] exuded by the host roots. SLs are plant hormones derived from plant carotenoids via a pathway involving the Carotenoid Cleavage Dioxygenase 8 (CCD8). Having no effective means to control parasitic weeds in most crops, and with CRISPR/Cas9 being an effective gene-editing tool, here we demonstrate that CRISPR/Cas9-mediated mutagenesis of the CCD8 gene can be used to develop host resistance to the parasitic weed P. aegyptiaca. Cas9/single guide (sg) RNA constructs were targeted to the second exon of CCD8 in tomato (Solanum lycopersicum L.) plants. Several
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