Evidence map›Paper›PMID 31391517›Full record

ArticleScientific reports2019

Encapsulation of Isoniazid-conjugated Phthalocyanine-In-Cyclodextrin-In-Liposomes Using Heating Method.

Christian Isalomboto Nkanga, Rui Werner Maçedo Krause

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

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  17. TheBiomaterials science · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christian Isalomboto NkangaCenter for Chemico- and Bio-Medicinal Research (CCBR), Department of Chemistry, Rhodes University, PO Box 94, Grahamstown, 6140, Eastern Cape, South Africa.ORCID http://orcid.org/0000-0001-7712-478X
Rui Werner Maçedo KrauseCenter for Chemico- and Bio-Medicinal Research (CCBR), Department of Chemistry, Rhodes University, PO Box 94, Grahamstown, 6140, Eastern Cape, South Africa. r.krause@ru.ac.za.ORCID http://orcid.org/0000-0001-6788-6449
Rhodes University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes are reputed colloidal vehicles that hold the promise for targeted delivery of anti-tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis. However, the costly status of liposome technology, particularly due to the use of special manufacture equipment and expensive lipid materials, may preclude wider developments of therapeutic liposomes. In this study, we report efficient encapsulation of a complex system, consisting of isoniazid-hydrazone-phthalocyanine conjugate (Pc-INH) in gamma-cyclodextrin (γ-CD), in liposomes using crude soybean lecithin by means of a simple organic solvent-free method, heating method (HM). Inclusion complexation was performed in solution and solid-state, and evaluated using UV-Vis, magnetic circular dichroism,

Indexed as

Antitubercular AgentsChemistry, PharmaceuticalCyclodextrinsDelayed-Action PreparationsDrug CompoundingDrug LiberationDrug StabilityHot TemperatureHumansHydrazonesHydrogen-Ion ConcentrationIndolesIsoindolesIsoniazidLiposomesParticle SizeAntitubercular AgentsCyclodextrinsDelayed-Action PreparationsHydrazonesIndolesIsoindolesIsoniazidLiposomesphthalocyanine

Identifiers

PMID31391517
PMCPMC6685989
OpenAlexW2964409336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.