Evidence map›Paper›PMID 31391503›Full record

ArticleScientific reports2019

10 kHz SCS therapy for chronic pain, effects on opioid usage: Post hoc analysis of data from two prospective studies.

Adnan Al-Kaisy, Jean-Pierre Van Buyten, Roy Carganillo, David Caraway, Bradford Gliner, Jeyakumar Subbaroyan, Catherine Panwar, Anand Rotte, Kasra Amirdelfan, Leonardo Kapural

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

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  4. Pain, quality of life, and function in chronic intractable leg pain were substantially improved with 10kHz spinal cord stimulation in a multicentre European study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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  18. Improving care of chronic pain patients with spinal cord stimulator therapy amidst the opioid epidemic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Adnan Al-KaisyThe Pain Management and Neuromodulation Centre, Guy's and St. Thomas' Hospital, London, UK.
Jean-Pierre Van BuytenMultidisciplinary Pain Centre, AZ Nikolaas, St Niklaas, Belgium.
Roy CarganilloThe Pain Management and Neuromodulation Centre, Guy's and St. Thomas' Hospital, London, UK.
David CarawayNevro Corp. 1800 Bridge Parkway, Redwood City, CA, USA.
Bradford GlinerNevro Corp. 1800 Bridge Parkway, Redwood City, CA, USA.
Jeyakumar SubbaroyanNevro Corp. 1800 Bridge Parkway, Redwood City, CA, USA.
Catherine PanwarPanwar Health, Sydney, NSW, 2036, Australia.
Anand RotteNevro Corp. 1800 Bridge Parkway, Redwood City, CA, USA. anand.rotte@nevro.com.
Kasra AmirdelfanIPM Medical Group, Inc., Walnut Creek, California, USA.
Leonardo KapuralCarolina's Pain Institute, Winston-Salem, North Carolina, USA.
Nevro (United States) · USSt Thomas' Hospital · GBCarolinas Pain Institute · USVlaamse Vereniging voor Obstetrie en Gynaecolo · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain, including chronic low back and leg pain are prominent causes of disability worldwide. While patient management aims to reduce pain and improve daily function, prescription of opioids remains widespread despite significant adverse effects. This study pooled data from two large prospective trials on 10 kHz spinal cord stimulation (10 kHz SCS) in subjects with chronic low back pain and/or leg pain and performed post hoc analysis on changes in opioid dosage 12 months post 10 kHz SCS treatment. Patient-reported back and leg pain using the visual analog scale (VAS) and opioid dose (milligrams morphine equivalent/day, MME/day) were compared at 12 months post-10 kHz SCS therapy to baseline. Results showed that in the combined dataset, 39.3% of subjects were taking >90 MME dose of opioids at baseline compared to 23.0% at 12 months post-10 kHz SCS therapy (p = 0.007). The average dose of opioids in >90 MME group was significantly reduced by 46% following 10 kHz SCS therapy (p < 0.001), which was paralleled by significant pain relief (P < 0.001). In conclusion, current analysis demonstrates the benefits of 10 kHz SCS therapy and offers an evidence-based, non-pharmaceutical alternative to opioid therapy and/or an adjunctive therapy to facilitate opioid dose reduction whilst delivering significant pain relief. Healthcare providers involved in management of chronic non-cancer pain can include reduction or elimination of opioid use as part of treatment plan when contemplating 10 kHz SCS.

Indexed as

Spinal Cord StimulationAdultAgedAnalgesics, OpioidChronic PainDrug PrescriptionsDrug UtilizationFeasibility StudiesFemaleFollow-Up StudiesHumansLow Back PainMaleMiddle AgedPain ManagementPain MeasurementAnalgesics, Opioid

Identifiers

PMID31391503
PMCPMC6686020
OpenAlexW2966390668

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.