ArticleScientific reports2019
The relationship of comorbidities to mortality and cause of death in patients with differentiated thyroid carcinoma.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 43 citations in OpenAlex.
- Clinical outcomes in older adults with advanced thyroid cancer.The oncologist · 2026Article
- Subclinical myocardial dysfunction in treatment naive papillary thyroid carcinoma patients.Scientific reports · 2026Article
- Roadmap for Representative Artificial Intelligence Models for Thyroid Cancer.The Laryngoscope · 2026Review
- A comparative study on the bilateral areolar endoscopic approach versus the conventional open thyroidectomy.Frontiers in surgery · 2026Article
- Impact of comorbidities on treatment management and prognosis in patients with anaplastic thyroid cancer (ATC).Journal of cancer research and clinical oncology · 2025Article
- Article
- KIF23 silencing suppresses papillary thyroid carcinoma metastasis by regulating mitophagy via Wnt/β-catenin pathway.Endocrine connections · 2025Article
- Ultrasound features and thyroid function of patients with papillary thyroid carcinoma for predicting metastatic cervical lymph nodes with atypical ultrasound features.Frontiers in oncology · 2025Article
- Prediction of TNFRSF9 expression and molecular pathological features in thyroid cancer using machine learning to construct Pathomics models.Endocrine · 2024Article
- Article
- Disparities in Thyroid Cancer Diagnosis Based on Residence and Distance From Medical Facility.Journal of the Endocrine Society · 2024Article
- All-Cause and Cause-Specific Mortality Among Low-Risk Differentiated Thyroid Cancer Survivors in the United States.Thyroid : official journal of the American Thyroid Association · 2024Article
- Clinical value of dual-energy CT for predicting occult metastasis in central neck lymph nodes of papillary thyroid carcinoma.European radiology · 2024Article
- Assessment of preoperative health-related quality of life in patients undergoing thyroidectomy based on patient-reported outcomes.Frontiers in psychology · 2024Article
- Review
- Food insecurity, mental health and in-hospital mortality following the COVID-19 pandemic in a socially deprived UK coastal town.BMJ nutrition, prevention & health · 2023Article
- Predictive nomogram for central lymph node metastasis in papillary thyroid microcarcinoma based on pathological and ultrasound features.Frontiers in endocrinology · 2023Article
- Initial clinical and treatment patterns of advanced differentiated thyroid cancer: ERUDIT study.European thyroid journal · 2022Article
- Surgery and Radioactive Iodine Therapeutic Strategy for Patients Greater Than 60 Years of Age with Differentiated Thyroid Cancer.Journal of healthcare engineering · 2022Article
- Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how comorbidities contribute to death in cancer patients is becoming an important topic. The present study assessed the role of comorbidities in overall mortality and causes of death in patients with differentiated thyroid carcinoma (DTC). This retrospective cohort study included 2070 patients who underwent thyroidectomy for DTC at a single institution between 2002 and 2005. Probabilities of overall, DTC-specific and other-cause death were examined according to the number of comorbidities, with consideration for competing events. The estimated 15-year cumulative incidences of overall, DTC-specific, and other-cause death were 7.3%, 1.6%, and 5.7%, respectively. Taking the group without comorbidities as a reference, we found that the group with 1-2 comorbidities and the group with ≥3 comorbidities had higher probabilities of other-cause death (subhazard ratios = 2.48 and 9.41, respectively; p < 0.01) and consequently shorter overall survival (hazard ratio = 1.95 and 5.33, respectively; p < 0.01), with adjustment for age, sex, and tumor-node-metastasis classification. In contrast, the probability of DTC-specific death was reduced in patients with ≥3 comorbidities (subhazard ratio = 6.81e-10, p < 0.01). For overall death, the relative proportion of death from DTC reduced when the number of comorbidities increased, and DTC-specific death was not observed in patients with ≥3 comorbidities. Our results show that death from DTC itself accounted for only a fraction of the overall deaths among patients who underwent surgery for DTC. Comorbidities increased overall mortality by increasing the probability of other-cause death. Patients with multiple comorbidities had a low probability of dying from DTC because they died earlier from comorbidities.
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