ArticleScientific reports2019
MRI of Whole Rat Brain Perivascular Network Reveals Role for Ventricles in Brain Waste Clearance.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Vessel-Resolved Mapping of Perivascular Spaces Reveals Hierarchical Neurofluid OrganizationbioRxiv : the preprint server for biology · 2026Article
- Associations between ventricular boundary shift integral and composite cognitive domains across the alzheimer's disease continuum.Scientific reports · 2026Article
- Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.Nucleic acids research · 2025Article
- Review
- Early-Life Adversity Predicts Markers of Aging-Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women.Annals of neurology · 2025Article
- Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus.Frontiers in molecular neuroscience · 2025Article
- Interstitial fluid transport dynamics predict glioblastoma invasion and progression.npj biomedical innovations · 2025Article
- Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.bioRxiv : the preprint server for biology · 2024Article
- Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna.Immunity & ageing : I & A · 2024Article
- Impact of the Ventricle Size on Alzheimer's Disease Progression: A Retrospective Longitudinal Study.Dementia and neurocognitive disorders · 2024Article
- Review
- Perivascular network segmentations derived from high-field MRI and their implications for perivascular and parenchymal mass transport in the rat brain.Scientific reports · 2023Article
- Towards Standardisation of a Diffuse Midline Glioma Patient-Derived Xenograft Mouse Model Based on Suspension Matrices for Preclinical Research.Biomedicines · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- High-resolution 3D demonstration of regional heterogeneity in the glymphatic system.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model.Pharmaceutics · 2022Article
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Impaired Glymphatic Transport Kinetics Following Induced Acute Ischemic Brain Edema in a Mouse pMCAO Model.Frontiers in neurology · 2022Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Investigating the mechanisms by which metabolic wastes are cleared from nervous tissue is important for understanding natural function and the pathophysiology of several neurological disorders including Alzheimer's disease. Recent evidence suggests clearance may be the function of annular spaces around cerebral blood vessels, called perivascular spaces (PVS), through which cerebrospinal fluid (CSF) is transported from the subarachnoid space into brain parenchyma to exchange with interstitial fluid (also known as the glymphatic system). In this work, an MRI-based methodology was developed to reconstruct the PVS network in whole rat brain to better elucidate both PVS uptake and clearance pathways. MR visible tracer (Gd-albumin) was infused in vivo into the CSF-filled lateral ventricle followed by ex vivo high-resolution MR imaging at 17.6 T with an image voxel volume two orders of magnitude smaller than previously reported. Imaged tracer distribution patterns were reconstructed to obtain a more complete brain PVS network. Several PVS connections were repeatedly highlighted across different animals, and new PVS connections between ventricles and different parts of the brain parenchyma were revealed suggesting a possible role for the ventricles as a source or sink for solutes in the brain. In the future, this methodology may be applied to understand changes in the PVS network with disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.