Observational studyScientific reports2019
Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study.
Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Diastolic echocardiographic parameters identify pediatric kidney transplant recipients with structural myocardial alterations.Pediatric nephrology (Berlin, Germany) · 2026Article
- Hypertension control and its association with left ventricular hypertrophy in children and young people on dialysis: a longitudinal study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Dialysis-associated cardiovascular disease risk in children: mechanism and management.Pediatric nephrology (Berlin, Germany) · 2026Review
- Chronic Kidney Disease or Hypertension After Childhood Cancer.JAMA network open · 2025Article
- Alterations in diastolic function and cardiac geometry in children: a longitudinal study across the spectrum of dialysis and transplant.Pediatric nephrology (Berlin, Germany) · 2023Article
- Heart Failure with Preserved Ejection Fraction in Children.Pediatric cardiology · 2023Review
- Get to the heart of pediatric kidney transplant recipients: Evaluation of left- and right ventricular mechanics by three-dimensional echocardiography.Frontiers in cardiovascular medicine · 2023Article
- Subclinical cardiac dysfunction in pediatric kidney transplant recipients identified by speckle-tracking echocardiography.Pediatric nephrology (Berlin, Germany) · 2022Article
- Therapeutic Approaches in Heart Failure with Preserved Ejection Fraction (HFpEF) in Children: Present and Future.Paediatric drugs · 2022Review
- Diastolic Function and Ambulatory Hypertension in Children With Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2021Observational
- Hemodiafiltration maintains a sustained improvement in blood pressure compared to conventional hemodialysis in children-the HDF, heart and height (3H) study.Pediatric nephrology (Berlin, Germany) · 2021Observational
- Cardiac Ultrasound for the Nephrologist: Know Thy Heart to Know Thy Kidneys.Advances in chronic kidney disease · 2021Review
- Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease-A Pediatric Perspective.Frontiers in pediatrics · 2021Review
- High Fibroblast Growth Factor 23 as a Biomarker for Severe Cardiac Impairment in Children with Chronic Kidney Disease: A Single Tertiary Center Study.International journal of nephrology and renovascular disease · 2021Article
- Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study.BMC nephrology · 2020Observational
- Left ventricular stiffness in paediatric patients with end-stage kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
Corrections and comments
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Authors and funding
19 authors at 15 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with chronic kidney disease suffer from excessive cardiovascular mortality and early alterations of the cardiovascular system. Tissue doppler imaging is a validated echocardiographic tool to assess early systolic and diastolic cardiac dysfunction. We hypothesized that tissue Doppler velocities would reveal reduced cardiac function in children with chronic kidney disease compared to healthy children. A standardized echocardiographic exam was performed in 128 patients of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) Study aged 6-17 years with an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m
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Registered trials
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