ArticleProceedings of the National Academy of Sciences of the United States of America2019
Melanin-dot-mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed.
- Architecting NIR-II metal supramolecular dyes-illuminating the path to precision medicine.Chemical science · 2026Review
- Advances in applied supramolecular technologies 2021-2025.Chemical Society reviews · 2025Review
- Advances in mechanisms and challenges in clinical translation of synergistic nanomaterial-based therapies for melanoma.Frontiers in cell and developmental biology · 2025Review
- Visualization of Microcirculation at Acupoints in vivo of Alzheimer's Disease Animal Model with Photoacoustic Microscope: A Pilot Study.Journal of Alzheimer's disease reports · 2024Article
- Melanin/melanin-like nanoparticles: As a naturally active platform for imaging-guided disease therapy.Materials today. Bio · 2023Review
- A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity.Journal of nanobiotechnology · 2023Article
- Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Intraperitoneal administration for sustained photoacoustic contrast agent imaging.Photoacoustics · 2022Article
- Supramolecular Loading of DNA Hydrogels with Dye-Drug Conjugates for Real-Time Photoacoustic Monitoring of Chemotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Long wavelength-emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phenylthiol-BODIPY-based supramolecular metallacycles for synergistic tumor chemo-photodynamic therapy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamic Adjust of Non-Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR-II Imaging Mediated Photothermal Therapy and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments.Biomedicines · 2022Review
- Editorial: Stimuli-Responsive Emissive Organic and Metal-Organic Compounds.Frontiers in chemistry · 2022Article
- Rapidly liver-clearable rare-earth core-shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window.Journal of nanobiotechnology · 2021Article
- Amphiphilic Diketopyrrolopyrrole Derivatives for Efficient Near-Infrared Fluorescence Imaging and Photothermal Therapy.ACS omega · 2021Article
- Highly Sensitive Fluorescent pH Microsensors Based on the Ratiometric Dye Pyranine Immobilized on Silica Microparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Metal-Coordinated Supramolecular Self-Assemblies for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Anthracene-induced formation of highly twisted metallacycle and its crystal structure and tunable assembly behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Recent development of near-infrared photoacoustic probes based on small-molecule organic dye.RSC chemical biology · 2021Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.
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