Evidence map›Paper›PMID 31391294›Full record

ArticleThe oncologist2019

MET Genomic Alterations in Head and Neck Squamous Cell Carcinoma (HNSCC): Rapid Response to Crizotinib in a Patient with HNSCC with a Novel

Lisa Pei Chu, Debra Franck, Christine A Parachoniak, Jeffrey P Gregg, Michael G Moore, D Gregory Farwell, Shyam Rao, Andreas M Heilmann, Rachel L Erlich, Jeffrey S Ross and 3 more

Abstract readCase Reports
In one paragraph

Article in The oncologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lisa Pei ChuDepartment of Internal Medicine, Division of Hematology/Oncology, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA.ORCID 0000-0002-2491-382X
Debra FranckFoundation Medicine, Cambridge, Massachusetts, USA.
Christine A ParachoniakFoundation Medicine, Cambridge, Massachusetts, USA.
Jeffrey P GreggDepartment of Pathology, UC Davis School of Medicine, Sacramento, California, USA.
Michael G MooreDepartment of Otolaryngology, UC Davis School of Medicine, Sacramento, California, USA.
D Gregory FarwellDepartment of Otolaryngology, UC Davis School of Medicine, Sacramento, California, USA.
Shyam RaoDepartment of Radiation Oncology, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA.
Andreas M HeilmannFoundation Medicine, Cambridge, Massachusetts, USA.
Rachel L ErlichFoundation Medicine, Cambridge, Massachusetts, USA.
Jeffrey S RossFoundation Medicine, Cambridge, Massachusetts, USA.
Vincent A MillerFoundation Medicine, Cambridge, Massachusetts, USA.
Siraj AliFoundation Medicine, Cambridge, Massachusetts, USA.
Jonathan W RiessDepartment of Internal Medicine, Division of Hematology/Oncology, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA jwriess@ucdavis.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of effective targeted therapies for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) remains an unmet medical need. A patient with platinum-refractory recurrent oral cavity HNSCC underwent comprehensive genomic profiling (CGP) that identified an activating

Indexed as

CrizotinibGenomicsHumansMaleMiddle AgedMutationSquamous Cell Carcinoma of Head and NeckCrizotinib

Identifiers

PMID31391294
PMCPMC6795166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.