ArticleMolecular pharmacology2019
Structural Basis for Diltiazem Block of a Voltage-Gated Ca
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Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- An Unbiased Drug Screen in a Drosophila Model ofInternational journal of molecular sciences · 2026Article
- Cav1.2 facilitates the binding and internalisation of porcine epidemic diarrhoea virus.Veterinary research · 2025Article
- Harnessing Deep Learning Methods for Voltage-Gated Ion Channel Drug Discovery.Physiology (Bethesda, Md.) · 2025Review
- The Evolving Role of Calcium Channel Blockers in Hypertension Management: Pharmacological and Clinical Considerations.Current issues in molecular biology · 2024Review
- T-type voltage-gated channels, NaCell communication and signaling : CCS · 2024Article
- Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology.Channels (Austin, Tex.) · 2023Review
- RETRACTED: Repurposing Diltiazem for Its Neuroprotective Anti-Dementia Role against Intra-Cerebroventricular Streptozotocin-Induced Sporadic Alzheimer's Disease-Type Rat Model.Life (Basel, Switzerland) · 2023Article
- Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Impaired CaJournal of molecular and cellular cardiology · 2022Article
- Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain.Cell reports · 2022Article
- How Do Modulators Affect the Orthosteric and Allosteric Binding Pockets?ACS chemical neuroscience · 2022Article
- Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung.PLoS pathogens · 2022Article
- Magnetic Fields and Magnetically Stimulated Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Differentially Modulate L-Type Voltage-Gated Calcium Channel Activity in Midbrain Neurons.ACS applied nano materials · 2022Article
- ChanFAD: A Functional Annotation Database for Ion Channels.Frontiers in bioinformatics · 2022Article
- Article
- Aldosterone-Induced Sarco/Endoplasmic Reticulum CaFrontiers in physiology · 2022Article
- Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs.International journal of molecular sciences · 2021Article
- The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels.The Journal of international medical research · 2020Article
- L-type CaProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Association between gene polymorphisms of voltage-dependent CaBMC medical genetics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Lin TangDepartment of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China (L.T.); and Department of Pharmacology (L.T., T.M.G.E.-D., M.J.L., N.Z., W.A.C.), Division of General Internal Medicine, Department of Medicine (M.J.L.), and Howard Hughes Medical Institute (N.Z.), University of Washington, Seattle, Washington ltang@scu.edu.cn.
Tamer M Gamal El-DinDepartment of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China (L.T.); and Department of Pharmacology (L.T., T.M.G.E.-D., M.J.L., N.Z., W.A.C.), Division of General Internal Medicine, Department of Medicine (M.J.L.), and Howard Hughes Medical Institute (N.Z.), University of Washington, Seattle, Washington.
Michael J LenaeusDepartment of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China (L.T.); and Department of Pharmacology (L.T., T.M.G.E.-D., M.J.L., N.Z., W.A.C.), Division of General Internal Medicine, Department of Medicine (M.J.L.), and Howard Hughes Medical Institute (N.Z.), University of Washington, Seattle, Washington.
Ning ZhengDepartment of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China (L.T.); and Department of Pharmacology (L.T., T.M.G.E.-D., M.J.L., N.Z., W.A.C.), Division of General Internal Medicine, Department of Medicine (M.J.L.), and Howard Hughes Medical Institute (N.Z.), University of Washington, Seattle, Washington nzheng@uw.edu.
William A CatterallDepartment of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China (L.T.); and Department of Pharmacology (L.T., T.M.G.E.-D., M.J.L., N.Z., W.A.C.), Division of General Internal Medicine, Department of Medicine (M.J.L.), and Howard Hughes Medical Institute (N.Z.), University of Washington, Seattle, Washington wcatt@uw.edu.
Howard Hughes Medical Institute · USSichuan University · CNUniversity of Washington · US
Funding
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9MStructural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8MVOLTAGE-SENSITIVE SODIUM CHANNELS IN BRAINR01NS015751 · NINDS · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 1985 to 2018
$6.0MThe Structural Basis of Antiarrhythmic Drug Binding in Voltage-gated Ion ChannelsK08HL145630 · NHLBI · UNIVERSITY OF WASHINGTON · PI LENAEUS, MICHAEL J · 2019 to 2023
$816kNHLBI NIH HHS K08 HL145630NHLBI NIH HHS R01 HL112808NICHD NIH HHS U54 HD083091NINDS NIH HHS R01 NS015751
Abstract
Diltiazem is a widely prescribed Ca
Indexed as
Allosteric RegulationAmlodipineAnimalsBinding SitesCalcium Channel BlockersCalcium ChannelsCrystallography, X-RayDiltiazemHumansModels, MolecularProtein ConformationVerapamilAmlodipineCalcium Channel BlockersCalcium ChannelsDiltiazemVerapamil
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.