Evidence map›Paper›PMID 31391282›Full record

ArticlemSphere2019

Trypanosoma brucei Homologue of Regulator of Ribosome Synthesis 1 (Rrs1) Has Direct Interactions with Essential Trypanosome-Specific Proteins.

Daniel Jaremko, Martin Ciganda, Noreen Williams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daniel JaremkoDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.
Martin CigandaDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.
Noreen WilliamsDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA nw1@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Ribosomal biogenesis in trypanosomesR01GM110227 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WILLIAMS, NOREEN · 2014 to 2017
$1.2M
Targeting the trypanosomal preribosomal complexR01GM113890 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WILLIAMS, NOREEN · 2015 to 2018
$1.1M
Identifying Critical Interactions in the Unique Trypanosoma brucei 5S Ribonucleoprotein Complex and their Role in Ribosome BiogenesisF30GM125117 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JAREMKO, DANIEL · 2017 to 2020
$160k
NIGMS NIH HHS F30 GM125117NIGMS NIH HHS R01 GM110227NIGMS NIH HHS R01 GM113890
6 · The paper itself

Abstract

Studies in eukaryotic ribosome biogenesis have largely been performed in yeast, where they have described a highly complex process involving numerous protein and RNA components. Due to the complexity and crucial nature of this process, a number of checkpoints are necessary to ensure that only properly assembled ribosomes are released into the cytoplasm. Assembly of the 5S ribonucleoprotein (RNP) complex is one of these checkpoints for late-stage 60S subunit maturation. Studies in

Indexed as

Protein BindingProtozoan ProteinsRibosomesRNA-Binding ProteinsRNA InterferenceRNA, Ribosomal, 5STrypanosoma brucei bruceip34 protein, Trypanosoma bruceip37 protein, Trypanosoma bruceiProtozoan ProteinsRNA-Binding ProteinsRNA, Ribosomal, 5S5S rRNAprotein-proteinprotein-RNAribosome biogenesisRpf2Rrs1

Identifiers

PMID31391282
PMCPMC6686231
OpenAlexW2965462981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.