Evidence map›Paper›PMID 31391255›Full record

ArticleThe Journal of biological chemistry2019

Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling.

Zhaoquan Wang, Shelby M Hutcherson, Chao Yang, Rakhi P Jattani, Julia M Tritapoe, Yong-Kang Yang, Joel L Pomerantz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations.The Journal of allergy and clinical immunology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhaoquan WangDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Shelby M HutchersonDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Chao YangDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Rakhi P JattaniDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Julia M TritapoeDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Yong-Kang YangDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Joel L PomerantzDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 joel.pomerantz@jhmi.edu.ORCID 0000-0002-5030-1018
Johns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Regulation of CARD11 signaling in normal and dysregulated lymphocyte developmentR01CA177600 · NCI · JOHNS HOPKINS UNIVERSITY · PI POMERANTZ, JOEL L · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA177600NCI NIH HHS T32 CA009110NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

The activation of key signaling pathways downstream of antigen receptor engagement is critically required for normal lymphocyte activation during the adaptive immune response. CARD11 is a multidomain signaling scaffold protein required for antigen receptor signaling to NF-κB, c-Jun N-terminal kinase, and mTOR. Germline mutations in the

Indexed as

Adaptive ImmunityB-Cell CLL-Lymphoma 10 ProteinCARD Signaling Adaptor ProteinsGerm-Line MutationGuanylate CyclaseHumansJNK Mitogen-Activated Protein KinasesJurkat CellsLymphocyte ActivationMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinMultiprotein ComplexesNF-kappa BProtein BindingProtein ConformationReceptors, AntigenSignal TransductionB-Cell CLL-Lymphoma 10 ProteinCARD11 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseJNK Mitogen-Activated Protein KinasesMTOR protein, humanMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinMultiprotein ComplexesNF-kappa BReceptors, AntigenRNF31 protein, humanTOR Serine-Threonine KinasesUbiquitin-Protein Ligasesantigen receptorBcl10CARD11immunologyLUBACMALT1NF-kappa B (NF-κB)scaffold proteinsignal transductionubiquitylation (ubiquitination)

Identifiers

PMID31391255
PMCPMC6779434
OpenAlexW2967293046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.