Evidence map›Paper›PMID 31391254›Full record

ArticleThe Journal of biological chemistry2019

The small molecule nitazoxanide selectively disrupts BAM-mediated folding of the outer membrane usher protein.

John J Psonis, Peter Chahales, Nadine S Henderson, Nathan W Rigel, Paul S Hoffman, David G Thanassi

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  10. Antibacterial Discovery: 21st Century Challenges.Antibiotics (Basel, Switzerland) · 2020
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

John J PsonisDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794.
Peter ChahalesDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794.
Nadine S HendersonDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794.
Nathan W RigelDepartment of Biology, Hofstra University, Hempstead, New York 11549.
Paul S HoffmanDepartment of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia 22908.
David G ThanassiDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794 david.thanassi@stonybrook.edu.
Stony Brook University · USHofstra University · USUniversity of Virginia · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
Mechanism of the Usher in Assembly and Secretion of PiliR01GM062987 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI David G Thanassi · 2001 to 2026
$7.7M
MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
Small Molecule Inhibition of Pilus Biogenesis by Pathogenic BacteriaR21AI121639 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI THANASSI, DAVID G · 2016 to 2017
$406k
Instrumentation grant application for forteBio Octet Red96 Biolayer Interferometry SystemS10OD020155 · OD · STATE UNIVERSITY NEW YORK STONY BROOK · PI SEELIGER, MARKUS A · 2015 to 2015
$204k
NIAID NIH HHS R21 AI121639NIAID NIH HHS T32 AI007539NIGMS NIH HHS R01 GM062987NIGMS NIH HHS T32 GM008444NIH HHS S10 OD020155
6 · The paper itself

Abstract

Bacterial pathogens assemble adhesive surface structures termed pili or fimbriae to initiate and sustain infection of host tissues. Uropathogenic

Indexed as

Protein FoldingAntiparasitic AgentsBacterial Outer Membrane ProteinsEscherichia coli ProteinsMolecular ChaperonesNitro CompoundsThiazolesUropathogenic Escherichia coliAntiparasitic AgentsBacterial Outer Membrane ProteinsBamD protein, E coliCfaC protein, E coliEscherichia coli ProteinsMolecular ChaperonesnitazoxanideNitro CompoundsThiazolesbacteriabacterial outer membraneBam complexfimbriaenitazoxanideouter membranepiliprotein foldingprotein secretionsmall moleculeusher proteinvirulence factor

Identifiers

PMID31391254
PMCPMC6768635
OpenAlexW2964673044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.