Observational studyThe European respiratory journal2019
Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza.
Observational study in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Inhaled Ciclesonide for Community-Based COVID-19: A Placebo-Controlled Randomised Trial.Respirology (Carlton, Vic.) · 2026Trial
- Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient.Nature communications · 2026Article
- Multivariate Host-Pathogen Interactions Driving Heterogeneous Viral Shedding and CD8medRxiv : the preprint server for health sciences · 2025Article
- Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2024Review
- Enhancing immune regulationFrontiers in immunology · 2024Article
- Obesity dysregulates the pulmonary antiviral immune response.Nature communications · 2023Article
- Susceptibility of Patients with Airway Disease to SARS-CoV-2 Infection.American journal of respiratory and critical care medicine · 2022Article
- Review
- Co-infecting pathogens can contribute to inflammatory responses and severe symptoms in COVID-19.Journal of thoracic disease · 2022Article
- Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK.The Lancet. Respiratory medicine · 2021Article
- Why asthma might surprisingly protect against poor outcomes in COVID-19.The European respiratory journal · 2020Article
- Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.Science (New York, N.Y.) · 2020Article
- Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization.Respiratory medicine · 2020Observational
- Asthma and COPD in Hospitalized COVID-19 Patients.Archivos de bronconeumologia · 2020Article
- Seasonal and pandemic influenza: 100 years of progress, still much to learn.Mucosal immunology · 2020Review
- Insights Into Type I and III Interferons in Asthma and Exacerbations.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPatients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown. STUDY
settingA prospective observational study of adults with PCR-confirmed influenza in 11 UK hospitals, measuring nasal, nasopharyngeal and systemic immune mediators and whole-blood gene expression.
resultsOf 133 admissions, 40 (30%) had previous asthma; these were more often female (70%
conclusionsAsthma is common in those hospitalised with influenza, but may not represent classical type 2-driven disease. Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.