SynthesisThe European respiratory journal2019
A systematic review of comorbidities and outcomes of adult patients with pleural infection.
Synthesis in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Versus Long Antibiotic Course for Pleural Infection Management (SLIM Trial): a Randomized Controlled Open Label Trial
Antiseptic Pleural Irrigation for Patients With Pleural Infection
IrRigation of the INfected Pleural Space With antiSEptic Solution (RINSE) - a Proof of Concept Study
Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial-MIST-3.American journal of respiratory and critical care medicine · 2023Trial
- Day 3 blood urea nitrogen and discharge disposition in patients with pleural infection: a multicenter prospective study.Journal of thoracic disease · 2026Article
- Microbiological Profile and Antimicrobial Resistance Patterns of Pleural Fluid Isolates in a Tertiary Care Setting in Lahore, Pakistan.Molecular biotechnology · 2026Article
- Difference in clinical characteristics and outcomes between hospital-acquired and community-acquired pleural infection.MedScience · 2026Article
- Concurrent versus sequential intrapleural administration of fibrinolytic and DNase for pleural infections: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Bacteriology and clinical outcomes of pleural infections in Singapore: an 8-year retrospective observational study.Journal of thoracic disease · 2026Article
- What is new in pleural infections?Breathe (Sheffield, England) · 2026Review
- Successful two-port video-assisted thoracoscopic surgery for acute empyema in a high-risk patient with a high RAPID score: a case report.AME case reports · 2026Article
- Global point prevalence study to determine the variations in aetiology, management and outcomes of pleural infection: a protocol for the international multicentre study of pleural infection (the INTERMITTENT Study).BMJ open respiratory research · 2025Article
- U-shaped threshold-balanced extensive pleural lavage system for empyema: a retrospective case-control study on drainage efficiency and clinical outcomes.Journal of thoracic disease · 2025Article
- A Practical Approach to Pleural Infection.Pulmonary therapy · 2025Article
- Outcomes of adult empyema thoracis cases managed in a tertiary hospital in Uganda: a retrospective cohort study.BMC pulmonary medicine · 2025Article
- Pleural Space Diseases and Their Management: What is the Role of Intrapleural Fibrinolytic Therapy?The American surgeon · 2025Review
- Risk factors and prognostic predictors of recurrent bacterial empyema in patients after surgical treatment.BMC infectious diseases · 2025Article
- Pleural Infection: Diagnosis, Management, and Future Directions.Journal of clinical medicine · 2025Review
- Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis.Microbiology spectrum · 2025Observational
- Article
- Front-door thoracic ultrasound in patients with community-acquired pneumonia to diagnose and predict pleural infection: a prospective study.ERJ open research · 2024Article
- Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Associations of physical activity and quality of life in parapneumonic effusion patients.ERJ open research · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPleural infection remains an important cause of mortality. This study aimed to investigate worldwide patterns of pre-existing comorbidities and clinical outcomes of patients with pleural infection.
methodsStudies reporting on adults with pleural infection between 2000 and 2017 were identified from a search of Embase and MEDLINE. Articles reporting exclusively on tuberculous, fungal or post-pneumonectomy infection were excluded. Two reviewers assessed 20 980 records for eligibility.
results211 studies met the inclusion criteria. 134 articles (227 898 patients, mean age 52.8 years) reported comorbidity and/or outcome data. The majority of studies were retrospective observational cohorts (n=104, 78%) and the most common region of reporting was East Asia (n=33, 24%) followed by North America (n=27, 20%). 85 articles (50 756 patients) reported comorbidity. The median (interquartile range (IQR)) percentage prevalence of any comorbidity was 72% (58-83%), with respiratory illness (20%, 16-32%) and cardiac illness (19%, 15-27%) most commonly reported. 125 papers (192 298 patients) reported outcome data. The median (IQR) length of stay was 19 days (13-27 days) and median in-hospital or 30-day mortality was 4% (IQR 1-11%). In regions with high-income economies (n=100, 74%) patients were older (mean 56.5
conclusionPatients with pleural infection have high levels of comorbidity and long hospital stays. Most reported data are from high-income economy settings. Data from lower-income regions is needed to better understand regional trends and enable optimal resource provision going forward.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.