Evidence map›Paper›PMID 31391021›Full record

ArticleBMC public health2019

Risk factors for depression in elderly diabetic patients and the effect of metformin on the condition.

Fenqin Chen, Guozhu Wei, Yingfang Wang, Tingting Liu, Ting Huang, Qian Wei, Guojing Ma, Difei Wang

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

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  19. Prevalence of Mental Health Disorders among Elderly Diabetics and Associated Risk Factors in Indonesia.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fenqin ChenDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Guozhu WeiDepartment of Radiology, Orthopedic Hospital of Shenyang, Shenyang, 110001, China.
Yingfang WangDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Tingting LiuDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Ting HuangDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Qian WeiDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Guojing MaDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Difei WangDepartment of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China. wdf8lm@163.com.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

Foundation of Liaoning Province Education Administration L2015564Science and Technology Plan Project of Liaoning AF-SOP-07-1.0-01Shenyang Science and Technology Bureau F17-231-1-56
6 · The paper itself

Abstract

backgroundAt present, only a few studies have focused on the risk factors for depression in elderly diabetic patients, and there is little evidence for the effect of metformin in depressed elderly patients with diabetes than on its effect on blood glucose. The aim of the current work was to study the risk factors for depression in elderly diabetic patients and to ascertain the effects of metformin on the depressive state.

methodsWe initiated a 1:4 matched case-control study. The case group comprised 110 elderly diabetic patients with depression from nine communities in Shenyang in 2017. The control group comprised 440 non-depressed elderly diabetic patients from the same communities, which were matched by gender and age (± 2 years of age) with the case group. Depression was measured using the Geriatric Depression Scale-15, and we performed matched univariate and multivariate logistic regression analyses.

resultsIn the multivariate analysis, overweight status, poor physical capabilities and low activity level, and the presence of more than two additional illnesses were risk factors for depression in elderly patients with diabetes. For these risk factors, the adjusted ORs (all P < 0.05) were as follows: an adjusted OR of 2.031 and 95% CI of 1.180-3.495; an adjusted OR of 2.342 and 95% CI of 1.465-3.743; and an adjusted OR of 5.350 and 95% CI of 2.222-12.883, respectively. Patients taking metformin had a lower risk of depression than those taking no medication, with an adjusted OR of 0.567 and 95% CI of 0.323-0.997 (P < 0.05).

conclusionsOverweight status, poor physical capabilities and low activity level, and the presence of more than two additional illnesses were risk factors for depression in elderly diabetic patients, and metformin was a protective factor against depression in elderly diabetic patients.

Indexed as

AgedCase-Control StudiesDepressionDiabetes MellitusFemaleHumansHypoglycemic AgentsMaleMetforminMiddle AgedRisk FactorsHypoglycemic AgentsMetforminDepressionElderlyMetformin

Identifiers

PMID31391021
PMCPMC6686369
OpenAlexW2965957395

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.