Evidence map›Paper›PMID 31391003›Full record

Trial reportBMC infectious diseases2019

Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention.

T Charles Witzel, Michelle M Gabriel, Leanne McCabe, Peter Weatherburn, Mitzy Gafos, Andrew Speakman, Roger Pebody, Fiona M Burns, Chris Bonell, Fiona C Lampe and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

T Charles WitzelSigma Research, Department of Public Health, Environments & Society, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK. Charles.Witzel@lshtm.ac.uk.
Michelle M GabrielMRC Clinical Trials Unit at UCL, London, UK.
Leanne McCabeMRC Clinical Trials Unit at UCL, London, UK.
Peter WeatherburnSigma Research, Department of Public Health, Environments & Society, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.
Mitzy GafosMRC Clinical Trials Unit at UCL, London, UK.
Andrew SpeakmanInstitute for Global Health, UCL, London, UK.
Roger PebodyNAM Aidsmap, London, UK.
Fiona M BurnsInstitute for Global Health, UCL, London, UK.
Chris BonellDepartment of Public Health, Environments & Society, London School of Hygiene and Tropical Medicine, London, UK.
Fiona C LampeInstitute for Global Health, UCL, London, UK.
David T DunnMRC Clinical Trials Unit at UCL, London, UK.
Denise WardMRC Clinical Trials Unit at UCL, London, UK.
Justin HarbottleSH:24, London, UK.
Andrew N PhillipsInstitute for Global Health, UCL, London, UK.
Sheena McCormackMRC Clinical Trials Unit at UCL, London, UK.
Alison J RodgerInstitute for Global Health, UCL, London, UK.

Funding

Department of Health RP-PG-1212-20006Medical Research Council MC_UU_12023/23Programme Grants for Applied Research PG-1212-20006
6 · The paper itself

Abstract

backgroundThe SELPHI study (An HIV Self-Testing Public Health Intervention) is an online randomised controlled trial (RCT) of HIV self-testing (HIVST). The aim of this study was to assess the feasibility of recruiting UK men who have sex with men (cis and trans) and trans women who have sex with men to the SELPHI pilot, and the acceptability of the HIVST intervention used among those randomised to receive a kit.

methodsA mixed-methods approach to assessing trial feasibility and intervention acceptability was taken, using quantitative data from advertising sources and RCT surveys alongside qualitative data from a nested sub-study.

resultsOnline recruitment and intervention delivery was feasible. The recruitment strategy led to the registration of 1370 participants of whom 76% (1035) successfully enrolled and were randomised 60/40 to baseline testing vs no baseline testing. Advertising platforms performed variably. Reported HIVST kit use increased from 83% at two weeks to 96% at three months. Acceptability was very high across all quantitative measures. Participants described the instructions as easy to use, and the testing process as simple. The support structures in SELPHI were felt to be adequate. Described emotional responses to HIVST varied.

conclusionsRecruiting to a modest sized HIVST pilot RCT is feasible, and the recruitment, intervention and HIVST kit were acceptable. Research on support needs of individuals with reactive results is warranted.

Indexed as

Homosexuality, MaleMarketing of Health ServicesPatient Acceptance of Health CareTransgender PersonsAdolescentAdultEnglandFeasibility StudiesFemaleHealth SurveysHIV InfectionsHumansInternetMaleMiddle AgedPilot ProjectsHIV self-testingImplementation scienceMen who have sex with menOnline service deliveryProcess evaluationRandomised controlled trialTransgender people

Identifiers

PMID31391003
PMCPMC6686516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.