Evidence map›Paper›PMID 31390883›Full record

Trial reportArteriosclerosis, thrombosis, and vascular biology2019

ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors.

Natalie C Kegulian, Bastian Ramms, Steven Horton, Olgica Trenchevska, Dobrin Nedelkov, Mark J Graham, Richard G Lee, Jeffrey D Esko, Hussein N Yassine, Philip L S M Gordts

Open access · bronzeAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Arteriosclerosis, thrombosis, and vascular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Apolipoprotein C3: form begets function.Journal of lipid research · 2024
    Review
  11. Apolipoprotein-CIIIInternational journal of molecular sciences · 2023
    Article
  12. Apo CIII Proteoforms, Plasma Lipids, and Cardiovascular Risk in MESA.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Observational
  13. Quartet of APOCs and the Different Roles They Play in Diabetes.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Natalie C KegulianFrom the Department of Medicine, University of Southern California, Los Angeles (N.C.K., S.H., H.N.Y.).
Bastian RammsDepartment of Medicine (B.R., J.D.E., P.L.S.M.G.), University of California San Diego, La Jolla.
Steven HortonFrom the Department of Medicine, University of Southern California, Los Angeles (N.C.K., S.H., H.N.Y.).
Olgica TrenchevskaThe Biodesign Institute, Arizona State University, Tempe (O.T., D.N.).
Dobrin NedelkovThe Biodesign Institute, Arizona State University, Tempe (O.T., D.N.).
Mark J GrahamIonis Pharmaceuticals, Carlsbad, CA (M.J.G., R.G.L.).
Richard G LeeIonis Pharmaceuticals, Carlsbad, CA (M.J.G., R.G.L.).
Jeffrey D EskoDepartment of Medicine (B.R., J.D.E., P.L.S.M.G.), University of California San Diego, La Jolla.
Hussein N YassineFrom the Department of Medicine, University of Southern California, Los Angeles (N.C.K., S.H., H.N.Y.).
Philip L S M GordtsDepartment of Medicine (B.R., J.D.E., P.L.S.M.G.), University of California San Diego, La Jolla.
University of Southern California · USArizona State University · USUniversity of California, San Diego · USBielefeld University · DE

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
The delivery of essential fatty acids to the Brain in Alzheimer's diseaseR01AG054434 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$5.4M
Team Approach to Translate Novel Biomarkers for DiabetesR24DK090958 · NIDDK · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NELSON, RANDALL W, PEARSON, JAMES DAVID · 2011 to 2014
$4.5M
Biomarkers of ABCA1 mediated functions in Alzheimers diseaseR01AG055770 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$4.2M
LIPID METABOLISM IN ANIMAL CELLSR01GM033063 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D · 1985 to 2019
$3.4M
Population-Based Proteomic Investigation of Type 2 Diabetes MellitusR01DK082542 · NIDDK · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NELSON, RANDALL W · 2010 to 2014
$3.0M
DHA brain delivery by APOE genotypeR21AG056518 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2018 to 2019
$464k
Exploring The Impact of Human Milk Oligosaccharides in AtherosclerosisR21HD089067 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BODE, LARS, GORDTS, PHILIP · 2017 to 2018
$426k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG055770NIA NIH HHS R21 AG056518NICHD NIH HHS R21 HD089067NIDDK NIH HHS R01 DK082542NIDDK NIH HHS R24 DK090958NIGMS NIH HHS R01 GM033063
6 · The paper itself

Abstract

objectiveApoC-III (apolipoprotein C-III) glycosylation can predict cardiovascular disease risk. Higher abundance of disialylated (apoC-III

conclusionsOur results indicate that HSPGs preferentially clear apoC-III

Indexed as

AnimalsApolipoprotein C-IIIDisease Models, AnimalGlycosylationHumansHypertriglyceridemiaLipoproteins, HDL3MaleMiceMolecular Targeted TherapyOligonucleotidesReceptors, LDLReference ValuesApolipoprotein C-IIIISIS 304801Lipoproteins, HDL3OligonucleotidesReceptors, LDLapolipoproteinscardiovascular diseasesglycoproteinsmass spectrometrytriglycerides

Identifiers

PMID31390883
PMCPMC6761044
OpenAlexW2967501203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.