Evidence map›Paper›PMID 31390828›Full record

ArticleInternational journal of molecular sciences2019

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors.

Yutong Sun, Zhe Wang, Hao Yang, Xuanli Zhu, Han Wu, Lu Ma, Fang Xu, Wei Hong, Hao Wang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yutong SunSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Zhe WangSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Hao YangSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Xuanli ZhuSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Han WuSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Lu MaSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Fang XuSchool of Postgraduate Education, Ningxia Medical University, Yinchuan 750004, China.
Wei HongSchool of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China. hongwei136@hotmail.com.
Hao WangSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. paxhw@yahoo.co.uk.

Funding

Key R&D Program of Ningxia 2018BFG02004National Natural Science Foundation of China 81660588National Natural Science Foundation of China 81773582Program for Leading Talents of Ningxia Province KJT2018004
6 · The paper itself

Abstract

Protein arginine methyltransferase 1 (PRMT1) can catalyze protein arginine methylation by transferring the methyl group from

Indexed as

Binding SitesDose-Response Relationship, DrugEnzyme InhibitorsHumansMethylationMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein-Arginine N-MethyltransferasesProtein BindingRepressor ProteinsStructure-Activity RelationshipTetrazoles1H-tetrazoleEnzyme InhibitorsPRMT1 protein, humanProtein-Arginine N-MethyltransferasesRepressor ProteinsTetrazolesbinding modeMOA studiesmolecular dynamic simulationsPRMT1structure-activity relationship (SAR)

Identifiers

PMID31390828
PMCPMC6695598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.