Evidence map›Paper›PMID 31390614›Full record

ArticleAnnals of nutrition & metabolism2019

Serum Polyunsaturated Fatty Acids in Middle Childhood and Body Mass Index Change Through Adolescence.

Kerry S Flannagan, Sheila Gahagan, Arun K Das, Raquel A Burrows, Betsy Lozoff, Eduardo Villamor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nutrition & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kerry S FlannaganDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Sheila GahaganDivision of Child Development and Community Health, University of California, San Diego, California, USA.
Arun K DasDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Raquel A BurrowsInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Betsy LozoffCenter for Human Growth and Development, University of Michigan, Ann Arbor, Michigan, USA.
Eduardo VillamorDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA, villamor@umich.edu.

Funding

Statistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1M
NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTSR01HD033487 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA, LOZOFF, BETSY · 1997 to 2016
$8.8M
Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular RiskR01HL088530 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA · 2008 to 2017
$5.0M
Fatty Acids, Adiposity, & Cardiometabolic Risk in AdolescenceR01HL117860 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA, VILLAMOR, EDUARDO · 2014 to 2016
$1.1M
NHLBI NIH HHS R01 HL088530NHLBI NIH HHS R01 HL117860NICHD NIH HHS R01 HD033487NIDDK NIH HHS U24 DK097153
6 · The paper itself

Abstract

backgroundPolyunsaturated fatty acids (PUFA) status in childhood may be associated with adiposity development.

objectiveTo assess associations of serum PUFA biomarkers in childhood with change in body mass index (BMI)-for-age Z scores (BMIZ) through adolescence.

methodsWe quantified serum PUFA at ages 5 and 10 years among 418 children from Santiago, Chile. BMI was measured at 5, 10, and 16 years. We compared BMIZ change through age 16 years between quartiles of PUFA at 5 and 10 years and PUFA change 5-10 years by fitting growth curves from mixed effects models.

resultsAt age 5 years, serum docosahexaenoic acid was inversely associated with BMIZ change from ages 5 to 16 years. At age 10 years, arachidonic acid (AA) was nonlinearly positively related to BMIZ change from ages 10 to 16 years. Change in AA and the Δ5-desaturase (D5D) activity index between 5 and 10 years were each positively associated with BMIZ change from ages 10 to 16 years. Change in eicosapentaenoic acid was inversely associated with change in BMIZ.

conclusionsSerum long-chain n-3 PUFA in middle childhood were associated with less BMI gain through adolescence, whereas AA and D5D activity was related to greater BMI gain.

Indexed as

Body Mass IndexAdolescentAge FactorsArachidonic AcidChildChileDelta-5 Fatty Acid DesaturaseDocosahexaenoic AcidsFatty Acid DesaturasesFatty Acids, UnsaturatedFemaleHumansLongitudinal StudiesMaleArachidonic AcidDelta-5 Fatty Acid DesaturaseDocosahexaenoic AcidsFatty Acid DesaturasesFatty Acids, UnsaturatedAdiposityAdolescentsBody mass indexChildrenChileGrowthPolyunsaturated fatty acids

Identifiers

PMID31390614
PMCPMC6827434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.