ArticleCell reports2019
Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing.Molecular psychiatry · 2026Article
- Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD.Translational psychiatry · 2025Article
- Evolutionary innovations in the primate dopaminergic system.Current opinion in genetics & development · 2024Review
- Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons.BMC neuroscience · 2024Article
- GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids.Frontiers in cellular neuroscience · 2024Review
- Genetics of human brain development.Nature reviews. Genetics · 2024Review
- Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus.Stem cell reports · 2023Article
- Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis.Current opinion in neurobiology · 2023Review
- From circuits to behavior: Amygdala dysfunction in fragile X syndrome.Frontiers in integrative neuroscience · 2023Review
- The effect of parietal glutamate/GABA balance on test anxiety levels in early childhood in a cross-sectional and longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Connectivity Mapping Using a NovelFrontiers in molecular neuroscience · 2022Article
- Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism.Molecular psychiatry · 2021Article
- Dynamic interplay between GABAergic networks and developing neurons in the adult hippocampus.Current opinion in neurobiology · 2021Review
- Sensory over-responsivity is related to GABAergic inhibition in thalamocortical circuits.Translational psychiatry · 2021Article
- A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms.Frontiers in cell and developmental biology · 2021Review
- The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully SymptomaticFrontiers in cellular neuroscience · 2021Article
- Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism.Molecular brain · 2020Article
- Sexually dimorphic role of oxytocin in medaka mate choice.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Does the brain's E:I balance really shape long-range temporal correlations? Lessons learned from 3T MRI.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
14 authors at 8 institutions in 4 countries.
Funding
Abstract
Excitation-inhibition (E-I) imbalance is considered a hallmark of various neurodevelopmental disorders, including schizophrenia and autism. How genetic risk factors disrupt coordinated glutamatergic and GABAergic synapse formation to cause an E-I imbalance is not well understood. Here, we show that knockdown of Disrupted-in-schizophrenia 1 (DISC1), a risk gene for major mental disorders, leads to E-I imbalance in mature dentate granule neurons. We found that excessive GABAergic inputs from parvalbumin-, but not somatostatin-, expressing interneurons enhance the formation of both glutamatergic and GABAergic synapses in immature mutant neurons. Following the switch in GABAergic signaling polarity from depolarizing to hyperpolarizing during neuronal maturation, heightened inhibition from excessive parvalbumin
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