Evidence map›Paper›PMID 31390531›Full record

ArticleResuscitation2019

Association of diastolic blood pressure with survival during paediatric cardiopulmonary resuscitation.

Caitlin E O'Brien, Polan T Santos, Michael Reyes, Shawn Adams, C Danielle Hopkins, Ewa Kulikowicz, Jennifer L Hamrick, Justin T Hamrick, Jennifer K Lee, Sapna R Kudchadkar and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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  19. Epinephrine Administration Intervals: Seeing the Forest for the Trees.American journal of respiratory and critical care medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Caitlin E O'BrienDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Polan T SantosDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Michael ReyesDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Shawn AdamsDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
C Danielle HopkinsDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Ewa KulikowiczDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Jennifer L HamrickDepartment of Anesthesiology, Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123 United States.
Justin T HamrickDepartment of Anesthesiology, Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123 United States.
Jennifer K LeeDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Sapna R KudchadkarDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States; Department of Pediatrics, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 United States.
Elizabeth A HuntDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States; Department of Pediatrics, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States; Division of Health Sciences Informatics, Johns Hopkins University School of Medicine, 2024 East Monument St. S 1-200, Baltimore, MD 21205 United States.
Raymond C KoehlerDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States.
Donald H ShaffnerDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Bloomberg Children's Center Suite 6302, Baltimore, MD 21287 United States. Electronic address: dshaffn1@jhmi.edu.
Bloomberg (United States) · USRady Children's Hospital-San Diego · US

Funding

Therapeutic Strategies for Neonatal Hypoxic-Ischemiic EncephalopathyR01NS060703 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES · 2008 to 2019
$3.9M
Training for Clinician Scientists in Pediatric Critical Cardiopulmonary DiseaseT32HL125239 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BEMBEA, MELANIA MARIA, EVERETT, ALLEN D · 2015 to 2024
$3.0M
End-tidal carbon dioxide (ETCO2) directed cardiopulmonary resuscitation (CPR)R21HD072845 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SHAFFNER, DONALD H · 2014 to 2015
$440k
NHLBI NIH HHS T32 HL125239NICHD NIH HHS R21 HD072845NINDS NIH HHS R01 NS060703
6 · The paper itself

Abstract

aimTo examine the relationship between survival and diastolic blood pressure (DBP) throughout resuscitation from paediatric asphyxial cardiac arrest.

methodsRetrospective, secondary analysis of 200 swine resuscitations. Swine underwent asphyxial cardiac arrest and were resuscitated with predefined periods of basic and advanced life support (BLS and ALS, respectively). DBP was recorded every 30 s. Survival was defined as 20-min sustained return of spontaneous circulation (ROSC).

resultsDuring BLS, DBP peaked between 1-3 min and was greater in survivors (20.0 [11.3, 33.3] mmHg) than in non-survivors (5.0 [1.0, 10.0] mmHg; p < 0.001). After this transient increase, the DBP in survivors progressively decreased but remained greater than that of non-survivors after 10 min of resuscitation (9.0 [6.0, 13.8] versus 3.0 [1.0, 6.8] mmHg; p < 0.001). During ALS, the magnitude of DBP change after the first adrenaline (epinephrine) administration was greater in survivors (22.0 [16.5, 36.5] mmHg) than in non-survivors (6.0 [2.0, 11.0] mmHg; p < 0.001). Survival rate was greater when DBP improved by ≥26 mmHg after the first dose of adrenaline (20/21; 95%) than when DBP improved by ≤10 mmHg (1/99; 1%). The magnitude of DBP change after the first adrenaline administration correlated with the timetoROSC (r = -0.54; p < 0.001).

conclusionsSurvival after asphyxial cardiac arrest is associated with a higher DBP throughout resuscitation, but the difference between survivors and non-survivors was reduced after prolonged BLS. During ALS, response to adrenaline administration correlates with survival and time to ROSC. If confirmed clinically, these findings may be useful for titrating adrenaline during resuscitation and prognosticating likelihood of ROSC. Institutional Protocol Numbers: SW14M223 and SW17M101.

Indexed as

AnimalsAsphyxiaBlood PressureCardiopulmonary ResuscitationDiastoleDisease Models, AnimalFollow-Up StudiesHeart ArrestRetrospective StudiesSurvival RateSwineCardiac arrestCardiopulmonary resuscitationDiastolic blood pressurePediatricsSurvivalSwine

Identifiers

PMID31390531
PMCPMC6769417
OpenAlexW2964795716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.