ArticleAmerican journal of physiology. Renal physiology2019
Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.
Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia after Running in the Heat.Medicine and science in sports and exercise · 2025Trial
- Rehydration effect of qingshu buye decoction on exercise and high temperature-induced dehydration.Journal of the International Society of Sports Nutrition · 2024Trial
- Article
- Nuclear Magnetic Resonance-Based Urinary Metabolic Profiling for Assessing Heat Stress-Related Incident Kidney Injury in Health-Care Workers.GeoHealth · 2026Article
- Disparity in the regulation and prevention of water versus sodium imbalance in heat-stress nephropathy: a phylogenetic perspective.Clinical kidney journal · 2026Review
- Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Evaluating the effects of heat strain and air pollution on kidney health.Environment international · 2026Article
- Oxidative Stress in Heat Stress Nephropathy: Crosstalk.Oxidative medicine and cellular longevity · 2026Review
- Rising Global Temperatures and Kidney Health: A Comprehensive Review of Current Evidence.Life (Basel, Switzerland) · 2025Review
- Longitudinal associations and interactions of heat and metal(loid) exposure with kidney outcomes in Mexican agricultural workers.Environmental research · 2025Article
- Influence of Foot and Legwear Color on Lower-Limb Temperature in Baseball Players Under Heat Stress.Sports (Basel, Switzerland) · 2025Article
- One day of environment-induced heat stress causes injury to the murine kidney.Experimental physiology · 2025Article
- Early body temperature trajectories and short term prognosis in sepsis associated acute kidney injury.Scientific reports · 2025Article
- Rest, shade, hydration and hygiene for the prevention of kidney injuries and inflammation in a Nicaraguan sugarcane worker cohort.Occupational and environmental medicine · 2025Article
- Predictors of Successful Whole-Body Hyperthermia in Cancer Patients: Target Temperature Achievement and Safety Analysis.Cancers · 2025Article
- Hyperthermia Predicts Cross-Shift Acute Kidney Injury Risk in Construction Workers.Kidney international reports · 2025Article
- Nitric oxide: Potential therapeutic target in Heat Stress-induced Multiple Organ Dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Liver fatty acid-binding protein point-of-care testing detects heat-induced organ damage: a pilot study in Japanese male self-defense force personnel.Scientific reports · 2025Article
- Economic Analysis of a Rest-Shade-Hydration-Sanitation Program at a Nicaraguan Sugar Mill.Annals of global health · 2025Article
- Extreme Heat Exposure Induced Acute Kidney Injury through NLRP3 Inflammasome Activation in Mice.Environment & health (Washington, D.C.) · 2024Article
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Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
Abstract
An epidemic of chronic kidney disease of unknown etiology (Mesoamerican nephropathy) has emerged in hot regions of Central America. We have demonstrated that dehydration associated with recurrent heat exposure causes chronic kidney disease in animal models. However, the independent influence of core body temperature on kidney injury has not been explored. In the present study, we tested the hypothesis that kidney injury could be accelerated by increasing body temperature independent of external temperature. Wild-type mice were exposed to heat (39.5°C, 30 min, 2 times daily) with or without the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) for 10 days. Core temperature, renal function, proteinuria, and renal histological and biochemical analyses were performed. Isolated mitochondria markers of oxidative stress were evaluated from kidney tissue. DNP increased body core temperature in response to heat by 1°C (42 vs. 41°C), which was transient. The mild increase in temperature correlated with worsening albuminuria (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.