Observational studyThe Journal of clinical endocrinology and metabolism2019
Clinical Course of Nonfunctional Pituitary Microadenoma in Children: A Single-Center Experience.
Observational study in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases.Nature reviews. Endocrinology · 2024Guideline
- Pituitary incidentaloma: a Pituitary Society international consensus guideline statement.Nature reviews. Endocrinology · 2025Review
- Pediatric Pituitary Adenomas and Cysts: A 46-Year Population-Based Analysis.Journal of the Endocrine Society · 2025Article
- Etiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents.Endocrine · 2025Article
- Who and how to screen for endogenous hypercortisolism in adrenal and pituitary incidentaloma.Journal of endocrinological investigation · 2025Review
- Minimizing unnecessary brain magnetic resonance imaging in pediatric endocrinology: a retrospective cohort analysis.Frontiers in endocrinology · 2024Article
- Clinical and therapeutic outcomes of pediatric pituitary adenomas: a single pituitary center experience.Endocrine · 2024Article
- An update on, and genetics of refractory adenomas of childhood.Pituitary · 2023Review
- Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?Endocrine · 2023Article
- Review
- Supratentorial Pediatric Midline Tumors and Tumor-like Lesions: Clinical Spectrum, Natural History and Treatment Options.Children (Basel, Switzerland) · 2022Review
- Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache.Journal of clinical medicine · 2021Article
- Dealing With Brain MRI Findings in Pediatric Patients With Endocrinological Conditions: Less Is More?Frontiers in endocrinology · 2021Review
- Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis.Frontiers in endocrinology · 2020Article
- Clinical Course of Nonfunctional Pituitary Microadenoma in Children: A Single-Center Experience.The Journal of clinical endocrinology and metabolism · 2019Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
contextPituitary lesions consistent with microadenomas are increasingly discovered by MRI. Sparse data are available on the long-term clinical and imaging course of such lesions in children.
objectiveThe aim of this study was to define the clinical and imaging course of pituitary lesions representing or possibly representing nonfunctioning microadenomas in children to guide clinical management.
designRetrospective observational study.
methodsThe clinical data warehouse at a tertiary care academic children's hospital was queried with the terms "pituitary" AND "microadenoma" and "pituitary" AND "incidentaloma." The electronic health records of the identified subjects were reviewed to extract data on the clinical and imaging course.
resultsA total of 78 children had nonfunctioning pituitary lesions incidentally discovered during clinical care, of which 44 (56%) were reported as presumed or possible microadenomas. In the children with microadenoma (median age 15 years, interquartile range 2), a majority (70%) underwent imaging for nonendocrine symptoms, the most common being headache (n = 16, 36%). No significant increase in the size of the microadenoma or cysts or worsening of pituitary function was seen over the average clinical follow-up of 4.5 ± 2.6 years. Four cases of drug-induced hyperprolactinemia resolved with discontinuation of the offending medication.
conclusionsAsymptomatic pituitary lesions representing cysts, microadenomas, or possible microadenomas follow a benign course in children. In the absence of new endocrine or visual symptoms, repeat MRI may not be needed, and if performed, should be done in no less than a year. When possible, it is prudent to discontinue hyperprolactinemia-inducing medications before imaging.
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