Evidence map›Paper›PMID 31389904›Full record

ReviewShock (Augusta, Ga.)2020

The Greater Omentum-A Vibrant and Enigmatic Immunologic Organ Involved in Injury and Infection Resolution.

Andrew W Wang, James M Prieto, David M Cauvi, Stephen W Bickler, Antonio De Maio

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Shock (Augusta, Ga.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  10. [Advances in intra-abdominal vascularized lymph node transfer for treatment of limb lymphedema].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  11. Article
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  14. Two Faces of Greater Omentum.Comprehensive physiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Andrew W WangDepartment of Surgery, Naval Medical Center San Diego, San Diego, California.
James M PrietoDepartment of Surgery, Naval Medical Center San Diego, San Diego, California.
David M CauviDivision of Trauma, Critical Care, Burns and Acute Surgery.
Stephen W BicklerDepartment of Surgery, School of Medicine, University of California, San Diego, La Jolla, California.
Antonio De MaioDivision of Trauma, Critical Care, Burns and Acute Surgery.
International Trauma Anesthesia and Critical Care Society · USNaval Medical Center San Diego · USUniversity of California, San Diego · US

Funding

Contribution of Cholesterol Homeostasis for Injury ResolutionR01GM114473 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DE MAIO, ANTONIO · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM114473
6 · The paper itself

Abstract

Once thought of as an inert fatty tissue present only to provide insulation for the peritoneal cavity, the omentum is currently recognized as a vibrant immunologic organ with a complex structure uniquely suited for defense against pathogens and injury. The omentum is a source of resident inflammatory and stem cells available to participate in the local control of infection, wound healing, and tissue regeneration. It is intimately connected with the systemic vasculature and communicates with the central nervous system and the hypothalamic pituitary adrenal axis. Furthermore, the omentum has the ability to transit the peritoneal cavity and sequester areas of inflammation and injury. It contains functional, immunologic units commonly referred to as "milky spots" that contribute to the organ's immune response. These milky spots are complex nodules consisting of macrophages and interspersed lymphocytes, which are gateways for the infiltration of inflammatory cells into the peritoneal cavity in response to infection and injury. The omentum contains far greater complexity than is currently conceptualized in clinical practice and investigations directed at unlocking its beneficial potential may reveal new mechanisms underlying its vital functions and the secondary impact of omentectomy for the staging and treatment of a variety of diseases.

Indexed as

HumansIntraabdominal InfectionsOmentumWound Healing

Identifiers

PMID31389904
PMCPMC7000303
OpenAlexW2967129168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.