Evidence map›Paper›PMID 31389742›Full record

ArticleJournal of neurophysiology2019

Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea.

Elizabeth P Ott, Sarah E Baker, Walter W Holbein, J Kevin Shoemaker, Jacqueline K Limberg

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. The effect of hyperoxia on muscle sympathetic nerve activity: a systematic review and meta-analysis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Pooled it
  2. Article
  3. Article
  4. Advancements in the neurocirculatory reflex response to hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Review
  5. Article
  6. Sympathetic transduction to blood pressure during euglycemic-hyperinsulinemia in young healthy adults: role of burst amplitude.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  7. Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  8. The impact of ageing and sex on sympathetic neurocirculatory regulation.Seminars in cell & developmental biology · 2021
    Review
  9. Review
  10. Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Elizabeth P OttDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Walter W HolbeinDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
J Kevin ShoemakerSchool of Kinesiology, University of Western Ontario, London, Ontario, Canada.
Jacqueline K LimbergDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Mayo Clinic · USUniversity of Missouri · USWestern University · CA

Funding

Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesR00HL130339 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2017 to 2019
$729k
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesK99HL130339 · NHLBI · MAYO CLINIC ROCHESTER · PI LIMBERG, JACQUELINE K · 2016 to 2017
$156k
NHLBI NIH HHS K99 HL130339NHLBI NIH HHS R00 HL130339
6 · The paper itself

Abstract

We sought to examine the effect of varying chemoreflex stress on sympathetic neural recruitment strategies during end-expiratory apnea. We hypothesized that increases in the firing frequency and probability of low-threshold axons at the asphyxic "break point" would be exaggerated during hypoxia and attenuated during hyperoxia. Multiunit muscle sympathetic nervous system activity (MSNA) (peroneal nerve microneurography) was measured in 10 healthy male subjects (31 ± 2 yr, 25 ± 1 kg/m

Indexed as

Recruitment, NeurophysiologicalReflexAction PotentialsAdultApneaCarbon DioxideCarotid BodyHumansMaleOxygenPeroneal NerveStress, PhysiologicalSympathetic Nervous SystemCarbon DioxideOxygenbreath holdcarotid bodyhyperoxiahypoxiamicroneurography

Identifiers

PMID31389742
PMCPMC6843108
OpenAlexW2966045352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.