Evidence map›Paper›PMID 31389674›Full record

SynthesisJournal of cachexia, sarcopenia and muscle2019

Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis.

Jorne Ubachs, Janine Ziemons, Iris J G Minis-Rutten, Roy F P M Kruitwagen, Jos Kleijnen, Sandrina Lambrechts, Steven W M Olde Damink, Sander S Rensen, Toon Van Gorp

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  6. Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  19. Trial
  20. Effect of exercise on body composition among women with ovarian cancer.Journal of cancer survivorship : research and practice · 2023
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorne UbachsDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID 0000-0001-9498-6162
Janine ZiemonsDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Iris J G Minis-RuttenDepartment of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Roy F P M KruitwagenDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Jos KleijnenCAPHRI, School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.
Sandrina LambrechtsDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Steven W M Olde DaminkDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Sander S RensenDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Toon Van GorpDepartment of Obstetrics and Gynecology, Division of Gynaecological Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia is the loss of skeletal muscle mass and function that occurs with advancing age and certain diseases. It is thought to have a negative impact on survival in cancer patients. Routine computed tomography imaging is often used to quantify skeletal muscle in cancer patients. Sarcopenia is defined by a low skeletal muscle index (SMI). Skeletal muscle radiation attenuation (SMRA) is used to define muscle quality. The primary aim of this meta-analysis was to study the association between sarcopenia or SMRA and overall survival (OS) or complications in patients with ovarian cancer.

methodsMedline, Embase, CINAHL, and PEDro databases were searched from inception to 15 February 2019. Studies evaluating the prognostic effect of SMI and SMRA on ovarian cancer survival or surgical complications were included. Risk of bias and study quality were evaluated with the Quality in Prognosis Studies Instrument (QUIPS) according to the modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework.

resultsThe search strategy yielded 4262 hits in all four databases combined. Ten and eight studies were included for qualitative and quantitative analysis, respectively. Meta-analysis revealed a significant association between the SMI and OS [0.007; hazard ratio (HR): 1.11, 95% confidence interval (CI): 1.03-1.20]. SMRA was also significantly associated with OS (P < 0.001; HR: 1.14, 95% CI: 1.08-1.20). Association between the SMI and surgical complications had borderline statistical significance (0.05; HR: 1.23, 95% CI: 1.00-1.52). The risk of bias assessed with QUIPS was high in all studies. The quality of the evidence was very low.

conclusionsWhereas our meta-analysis indicated that a low SMI and low SMRA are associated with survival in ovarian cancer patients, the low quality of the source data precludes drawing definitive conclusions.

Indexed as

AgedAged, 80 and overFemaleHumansMiddle AgedOvarian NeoplasmsPrognosisSarcopeniaSurvival AnalysisTomography, X-Ray ComputedCachexiaMeta-analysisOvarian cancerSarcopeniaSurvival

Identifiers

PMID31389674
PMCPMC6903439

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.