Evidence map›Paper›PMID 31389290›Full record

ReviewJournal of biological rhythms2019

Splicing the Clock to Maintain and Entrain Circadian Rhythms.

Iryna Shakhmantsir, Amita Sehgal

Open access · greenAbstract readReview
In one paragraph

Review in Journal of biological rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Iryna ShakhmantsirHoward Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-2138-0236
Amita SehgalHoward Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-7354-9641
Howard Hughes Medical Institute · US

Funding

Interaction between circadian and sleep circuitsR01NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AMITA SEHGAL · 2005 to 2026
$4.8M
Cycling in a circadian circuitR37NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA · 2015 to 2021
$2.7M
NINDS NIH HHS R01 NS048471NINDS NIH HHS R37 NS048471
6 · The paper itself

Abstract

Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcription. Although much of the focus with respect to clock mechanisms has been on the regulation of transcription and on the stability and activity of clock proteins, it is clear that other regulatory processes also have to be involved to explain aspects of clock function. Here, we review the role of alternative splicing in circadian clocks. Starting with a discussion of the

Indexed as

Alternative SplicingCircadian ClocksCircadian RhythmAnimalsCLOCK ProteinsDrosophila melanogasterDrosophila ProteinsEnvironmentHumansMiceTemperatureCLOCK ProteinsDrosophila Proteinsclock genesDrosophilafeedback loopsplicingtemperature entrainment

Identifiers

PMID31389290
PMCPMC10823935
OpenAlexW2965884887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.