Evidence map›Paper›PMID 31388743›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Effect of prior glaucoma surgery on intraocular pressure immediately after anti-vascular endothelial growth factor injection.

Jocelyn Lam, Ian Luttrell, Leona Ding, Kasra Rezaei, Jennifer R Chao, Yewlin Chee, Lisa C Olmos De Koo, Joanne C Wen

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jocelyn LamDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Ian LuttrellDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Leona DingDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Kasra RezaeiDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Jennifer R ChaoDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Yewlin CheeDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Lisa C Olmos De KooDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA.
Joanne C WenDepartment of Ophthalmology, University of Washington, 325 9th Ave, PO Box 359608, Seattle, WA, 98104-2499, USA. wenjc@uw.edu.ORCID http://orcid.org/0000-0002-8407-7819

Funding

Foundation for the National Institutes of Health Core Grant EY001830Research to Prevent Blindness Unrestricted Departmental Grant
6 · The paper itself

Abstract

backgroundTo characterize how prior incisional glaucoma surgery affects the intraocular pressure (IOP) elevation immediately following intravitreal anti-VEGF injections (IVI).

methodsSingle institution, experimental study. Patients with a history of incisional glaucoma surgery who were receiving anti-VEGF injections were recruited as well as control eyes. Pre- and post-injection IOP measurements were compared as well as time to recovery to within 5 and 10 mmHg of baseline IOP.

resultsTen eyes with a history of glaucoma surgery and 29 control eyes receiving anti-VEGF injections were included. The most common indication for intravitreal anti-VEGF injection was proliferative diabetic retinopathy in both surgical and control eyes (50% vs 45%, p = 1.00). Post-injection IOP was significantly decreased compared to baseline IOP after anti-VEGF injection in surgical versus control eyes (26.5 ± 8.9 mmHg vs 44.2 ± 8.5 mmHg, respectively, p < 0.001). The mean change in IOP following intravitreal anti-VEGF injection was lower in surgical eyes (10.7 ± 6.6 mmHg vs 28.6 ± 8.3 mmHg, p < 0.001). The mean time for the IOP to return to within 10 mmHg of pre-injection IOP was less in surgical eyes (5.2 ± 4.1 min vs 13.3 ± 7.6 min, p = 0.002).

conclusionsEyes with prior incisional glaucoma surgery demonstrated a significantly lower post-injection IOP elevation and a faster recovery to within 10 mmHg of their pre-injection IOP. Incisional glaucoma surgery may be considered for patients where the attenuation of post-injection IOP elevation is needed and other less invasive measures have failed.

Indexed as

AgedAngiogenesis InhibitorsBevacizumabFemaleFiltering SurgeryFollow-Up StudiesGlaucomaHumansIntraocular PressureIntravitreal InjectionsMaleMiddle AgedPreoperative PeriodProspective StudiesRanibizumabTonometry, OcularAngiogenesis InhibitorsBevacizumabRanibizumabVascular Endothelial Growth Factor AAnti-VEGF agentsGlaucoma surgeryIntraocular pressureIntravitreal injectionsOcular hypertension

Identifiers

PMID31388743

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.