Evidence map›Paper›PMID 31388703›Full record

Trial reportEuropean journal of clinical pharmacology2019

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study.

Victoria C Ziesenitz, Frédérique Rodieux, Andrew Atkinson, Carole Borter, Julia A Bielicki, Manuel Haschke, Urs Duthaler, Fabio Bachmann, Thomas O Erb, Nicolas Gürtler and 4 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02660177 (Single Center, Open-label, Prospective Study to Characterize the Pharmacokinetics of Metamizole and Its Metabolites Following Intravenous Administration in Children Less Than 6 Years Old), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02660177 phase2completednot on this map

Single Center, Open-label, Prospective Study to Characterize the Pharmacokinetics of Metamizole and Its Metabolites Following Intravenous Administration in Children Less Than 6 Years Old

TypeinterventionalSponsorUniversity Children's Hospital BaselRan2016 to 2017Enrolled33ConditionsChildren, Pain, SurgeryArmsMetamizole
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Victoria C Ziesenitz *Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Frédérique Rodieux *Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Andrew AtkinsonPediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Carole BorterPediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Julia A BielickiPediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Manuel HaschkeClinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, University Hospital, Bern, Switzerland.
Urs DuthalerDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University and University Hospital of Basel, Basel, Switzerland.
Fabio BachmannDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University and University Hospital of Basel, Basel, Switzerland.
Thomas O ErbPediatric Anesthesiology, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Nicolas GürtlerDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefan Holland-CunzPediatric Surgery, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Johannes N van den AnkerPediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Verena Gotta *Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland. verena.gotta@ukbb.ch.
Marc Pfister *Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
University Children’s Hospital Basel · CHUniversity of Basel · CHUniversity Hospital of Basel · CHUniversity Hospital Heidelberg · DEUniversity Hospital of Bern · CHUniversity of Bern · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung SNF 31003A_160216
6 · The paper itself

Abstract

purposeThe prodrug metamizole is prescribed intravenously for postoperative pain in children, including off-label use in infants < 1 year. We aimed to assess the pharmacokinetics of the main metabolites of metamizole in children aged 3-72 months.

methodsA single dose of 10 mg/kg metamizole was administered intravenously for postoperative analgesia. Pharmacokinetic samples were drawn at predefined time points. Pharmacokinetics of the main active metabolite 4-methylaminoantipyrine and three other metabolites was characterized by both non-compartmental and population pharmacokinetic analysis. AUC

resultsA total of 25 children aged 5 months-5.8 years (7.8-24.8 kg) with at least one concentration sample were included; 19 children had ≥ 5 predefined samples up to 10 h after metamizole dose administration. AUC

conclusionsAge-related changes in pharmacokinetics of 4-methylaminoantipyrine requires reduced weight-based IV dosing in infants < 1 year compared with infants and children up to 6 years (5 versus 10-20 mg/kg) to achieve equivalent adult exposure.

trial registrationClinicalTrials.gov identifier: NCT02660177 .

Indexed as

Models, BiologicalAdministration, IntravenousAnalgesicsAnti-Inflammatory Agents, Non-SteroidalChildChild, PreschoolDipyroneFemaleHumansInfantMalePostoperative PainAnalgesicsAnti-Inflammatory Agents, Non-SteroidalDipyroneChildrenDipyroneInfantsMetamizolePharmacokinetics

Identifiers

PMID31388703
OpenAlexW2965013084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.