ArticleToxicology reports2019
Investigating the potential protective effects of natural product quercetin against imidacloprid-induced biochemical toxicity and DNA damage in adults rats.
Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Synergistic reproductive toxicity of lambda-cyhalothrin and thiamethoxam via oxidative stress and blood-testis barrier dysfunction in rats.Scientific reports · 2026Article
- Article
- Effects of exposure to imidacloprid contaminated feed on the visceral organs of adult male rabbits (Saudi journal of biological sciences · 2023Article
- Imidacloprid Induces Neurotoxicity in Albino Male Rats by Inhibiting Acetylcholinesterase Activity, Altering Antioxidant Status, and Primary DNA Damage.Journal of toxicology · 2023Article
- Review
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- In vivo neurotoxic effects of emamectin benzoate in male mice: evaluation with enzymatic and biomolecular multi-biomarkers.Environmental science and pollution research international · 2022Article
- Effects of Sub-Chronic Exposure to Imidacloprid on Reproductive Organs of Adult Male Rats: Antioxidant State, DNA Damage, and Levels of Essential Elements.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Review
- Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat's kidney and HEK-293 cells.Toxicology reports · 2020Article
- Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole.Toxicology reports · 2020Article
- Testicular protective and antioxidant effects of selenium nanoparticles on Monosodium glutamate-induced testicular structure alterations in male mice.Toxicology reports · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quercetin (QT) is a natural antioxidant materials that's possesses different type of pharmacological activities. In the current study, the protective effect QT against imidacloprid (IMD)-induced toxicity in rats was studied. The experiment included thirty-six adult male rats groups treated with QT, IMD (two different doses), their combinations and control non-treated group for 21 consecutive days. Different biochemical analysis (serum liver and kidney enzymes level, cholesterol and Glucose levels) were evaluated. DNA damage using comet assay and histopathological examination of different body organs were also screened. Treatment with IMD increased ALT, AST, serum urea, creatinine, cholesterol and Glucose levels but decreased the levels of serum total protein, albumin and body weight with induction in triacylglycerol and cholesterol levels. Animals treated with QT prior to IMD administration showed normal enzymatic levels which indicating a protective effect of QT. In addition, QT protected the different body organs from the histological changes and DNA damages induced by IMD toxicity. The present results showed the protective effect of QT as a natural material against the IMD induced toxicity at different doses.
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