Evidence map›Paper›PMID 31388225›Full record

ArticleMedical journal, Armed Forces India2019

In the search of a 'fitness gene': an analysis of ACTN gene polymorphisms in serving soldiers.

Nikhil Moorchung, Bipin Puri, Vijay Bhatti, B L Lahareesh, S P Singh, Wankhede Tanaji Sitaram

Open access · bronzeAbstract read
In one paragraph

Article in Medical journal, Armed Forces India, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nikhil MoorchungAssistant Director, Institute of Bioinformatics, International Tech Park, Bengaluru 560066, India.
Bipin PuriDirector General Armed Forces Medical Services, O/o DGAFMS, Ministry of Defence, 'M' Block, New Delhi 110001, India.
Vijay BhattiDirector (H) AFMS, O/o DGAFMS, Ministry of Defence, New Delhi, India.
B L LahareeshRMO, 60 Para Field Hosp, C/o 56 APO, India.
S P SinghDADMS, HQ CE (P) Swastik, C/o 99 APO, India.
Wankhede Tanaji SitaramAssociate Professor, Department of Physiology, Armed Forces Medical College, Pune 411040, India.
Ministry of Defence · INArmed Forces Medical College · INInstitute of Bioinformatics · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic polymorphisms in the exon 15 and exon 16 of the ACTN3 gene are believed to be associated with athletic performance. Paratroopers are some of the fittest soldiers in the Indian Armed Forces. This study was taken up to assess if there was a significant difference in the genetic profile between paratroopers and non-paratroopers.

methodPolymerase chain reaction (PCR) followed by restriction length fragment polymorphism (RFLP) was used to analyse the genetic polymorphisms in the exon 15 and 16 of the ACTN3 gene.

resultsThere was a significant difference between paratroopers and non-paratroopers in the polymorphic loci at codon 15 and 16.

conclusionsThe study suggests that there is a significant difference in the genotype between paratroopers and non-paratroopers. It is likely that the differences in muscle fibres as a result of these genotypic changes confer a 'survival advantage'; people with a homozygous genotype are more likely to pass the harsh probation and qualify for the Parachute Regiment.

Indexed as

ACTN geneAthletesBody Mass IndexGenetic polymorphismsPhysical fitness

Identifiers

PMID31388225
PMCPMC6676326
OpenAlexW2964364049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.