Evidence map›Paper›PMID 31388185›Full record

Trial reportBritish journal of cancer2019

Tumour-infiltrating CD8

Mark A Glaire, Enric Domingo, Anita Sveen, Jarle Bruun, Arild Nesbakken, George Nicholson, Marco Novelli, Kay Lawson, Dahmane Oukrif, Wanja Kildal and 6 more

Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Identification of a gene score related to antigen processing and presentation machinery for predicting prognosis in head and neck squamous cell carcinoma and its potential implications for immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Mark A GlaireCancer Genomics and Immunology Group, The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Enric DomingoCancer Genomics and Immunology Group, The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Anita SveenDepartment of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway.
Jarle BruunDepartment of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway.
Arild NesbakkenDepartment of Gastroenterological Surgery & K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway.
George NicholsonDepartment of Statistics, University of Oxford, Oxford, UK.
Marco NovelliDepartment of Histopathology, UCL, Rockefeller Building, University Street, London, WC1E 6JJ, UK.
Kay LawsonDepartment of Histopathology, UCL, Rockefeller Building, University Street, London, WC1E 6JJ, UK.
Dahmane OukrifDepartment of Histopathology, UCL, Rockefeller Building, University Street, London, WC1E 6JJ, UK.
Wanja KildalInstitute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.
Havard E DanielsenInstitute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.
Rachel KerrOxford Cancer Centre, Churchill Hospital, Oxford University Hospitals Foundation NHS Trust, Oxford, UK.
David KerrNuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, OX3 9 DU, UK.
Ian TomlinsonInstitute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Ragnhild A LotheDepartment of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway.
David N ChurchCancer Genomics and Immunology Group, The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. dchurch@well.ox.ac.uk.
Oslo University Hospital · NOUniversity College London · GBUniversity of Oslo · NOUniversity of Oxford · GBGenomics (United Kingdom) · GBChurchill Hospital · GBUniversity of Birmingham · GB

Funding

Cancer Research UK 27963Cancer Research UK C399/A2291Cancer Research UK C6199/A10417Department of HealthWellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

backgroundIntratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group.

methodsWe performed a pooled analysis of 1804 CRCs from the QUASAR2 and VICTOR trials. Intratumoural CD8

resultsIn QUASAR2, intratumoural CD8

conclusionsThe prognostic value of intratumoural CD8

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsBevacizumabCapecitabineCD8-Positive T-LymphocytesCohort StudiesColorectal NeoplasmsFemaleFollow-Up StudiesHumansLactonesLymphocytes, Tumor-InfiltratingMaleNeoplasm Recurrence, LocalNeoplasm StagingSulfonesBevacizumabCapecitabineLactonesrofecoxibSulfones

Identifiers

PMID31388185
PMCPMC6738075
OpenAlexW2963701835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.