Evidence map›Paper›PMID 31388125›Full record

GuidelineNature reviews. Clinical oncology2019

Global Consultation on Cancer Staging: promoting consistent understanding and use.

James Brierley, Brian O'Sullivan, Hisao Asamura, David Byrd, Shao Hui Huang, Anne Lee, Marion Piñeros, Malcolm Mason, Fabio Y Moraes, Wiebke Rösler and 4 more

Abstract readPractice GuidelineReview
In one paragraph

Guideline in Nature reviews. Clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Exercise as supportive care in advanced cancer-related weight loss: a feasibility study comparing patients with and without severe weight loss.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
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  8. Article
  9. Prediction and Prognostication of Peripheral Blood Biomarkers in Head and Neck Cutaneous Squamous Cell Carcinoma.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  10. Article
  11. Article
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  13. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

James BrierleyDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. james.brierley@rmp.uhn.on.ca.ORCID http://orcid.org/0000-0002-6944-8394
Brian O'SullivanDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Hisao AsamuraKeio University School of Medicine, Tokyo, Japan.
David ByrdDepartment of Surgery, University of Washington, Seattle, WA, USA.
Shao Hui HuangDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Anne LeeDepartment of Clinical Oncology, The University of Hong Kong and the University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Marion PiñerosCancer Surveillance Section, International Agency for Research on Cancer, Lyon, France.
Malcolm MasonSchool of Medicine, Cardiff University, Cardiff, UK.
Fabio Y MoraesDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Wiebke RöslerUnion for International Cancer Control (UICC), Geneva, Switzerland.
Brian RousNational Cancer Registration Service, London, UK.
Julie TorodeUnion for International Cancer Control (UICC), Geneva, Switzerland.
J Han van KriekenRadboud University Medical Center, Nijmegen, Netherlands.
Mary GospodarowiczDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Disease burden is the most important determinant of survival in patients with cancer. This domain, reflected by the cancer stage and codified using the tumour-node-metastasis (TNM) classification, is a fundamental determinant of prognosis. Accurate and consistent tumour classification is required for the development and use of treatment guidelines and to enable clinical research (including clinical trials), cancer surveillance and control. Furthermore, knowledge of the extent and stage of disease is frequently important in the context of translational studies. Attempts to include additional prognostic factors in staging classifications, in order to facilitate a more accurate determination of prognosis, are often made with a lack of knowledge and understanding and are one of the main causes of the inconsistent use of terms and definitions. This effect has resulted in uncertainty and confusion, thus limiting the utility of the TNM classification. In this Position paper, we provide a consensus on the optimal use and terminology for cancer staging that emerged from a consultation process involving representatives of several major international organizations involved in cancer classification. The consultation involved several steps: a focused literature review; a stakeholder survey; and a consultation meeting. This aim of this Position paper is to provide a consensus that should guide the use of staging terminology and secure the classification of anatomical disease extent as a distinct aspect of cancer classification.

Indexed as

Medical OncologyTerminology as TopicCenters for Disease Control and Prevention, U.S.ComprehensionConsensusGlobal HealthHumansInternationalityNational Cancer Institute (U.S.)NeoplasmsNeoplasm StagingPractice Patterns, Physicians'PrognosisUnited States

Identifiers

PMID31388125
PMCPMC7136160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.