Observational studyJournal of perinatology : official journal of the California Perinatal Association2019
Racial association and pharmacotherapy in neonatal opioid withdrawal syndrome.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Implicit Racial Bias in Evaluation of Neonatal Opioid Withdrawal Syndrome.Journal of racial and ethnic health disparities · 2025Trial
- A Structural Examination of Racial Differences in Pharmacologic Treatment Among Opioid Exposed Infants.Journal of racial and ethnic health disparities · 2026Article
- Actigraphy: An Adjunctive Method to Measure Irritability in Opioid-Exposed Newborns.Journal of nursing measurement · 2024Article
- The Influence of Mediators on the Relationship Between Antenatal Opioid Agonist Exposure and the Severity of Neonatal Opioid Withdrawal Syndrome.Maternal and child health journal · 2023Article
- Polygenic risk scores and the need for pharmacotherapy in neonatal abstinence syndrome.Pediatric research · 2023Article
- Article
- Conflating Race and Genetics Among Newborns With Neonatal Abstinence Syndrome.JAMA pediatrics · 2022Article
- Within-Hospital Concordance of Opioid Exposure Diagnosis Coding in Mothers and Newborns.Hospital pediatrics · 2021Article
- Racial differences in opioid withdrawal syndrome among neonates with intrauterine opioid exposure.Pediatric research · 2021Observational
- Predictors of pharmacologic therapy for neonatal opioid withdrawal syndrome: a retrospective analysis of a statewide database.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Phenobarbital and Clonidine as Secondary Medications for Neonatal Opioid Withdrawal Syndrome.Pediatrics · 2021Article
- Racial and Ethnic Disparities in Maternal and Infant Outcomes Among Opioid-Exposed Mother-Infant Dyads in Massachusetts (2017-2019).American journal of public health · 2020Article
- Commentary on salivary cortisol levels as a biomarker for severity of withdrawal in opioid-exposed newborns.Pediatric research · 2020Article
- Racial association and pharmacotherapy in neonatal opioid withdrawal syndrome: thinking beyond genetics.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Response to racial association and pharmacotherapy in neonatal opioid withdrawal syndrome: thinking beyond genetics.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if racial differences are associated with Neonatal Opioid Withdrawal Syndrome (NOWS) severity. STUDY
designA 10-year (2008-2017) retrospective cohort of infants ≥35 weeks gestation with prenatal exposure to opioids was included. The primary measure was the need for pharmacotherapy. Multivariable logistic regression and propensity score analysis were performed.
resultsAmong 345 infants with NOWS, 111 (32%) were black infants with 70% of them requiring pharmacotherapy as compared with 84% of white infants. Upon adjusting for significant covariates (methadone, benzodiazepine use, and gestational age), black infants were 57% less likely than whites to require pharmacotherapy (Odds ratio: 0.43, 95%CI: 0.22-0.80, p = 0.009). Similar results were observed with propensity score analysis.
conclusionsSignificant racial disparity observed may be secondary to genetic variations in opioid pharmacogenomics and/or extrinsic factors. Large-scale studies are warranted to include race in predictive models for early pharmacological intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.