Evidence map›Paper›PMID 31388112›Full record

ArticleJournal of human genetics2019

Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.

Stephanie Wang, Emily Chang, Patrick Byanyima, Peter Huang, Ingvar Sanyu, Emmanuel Musisi, Abdul Sessolo, J Lucian Davis, William Worodria, Laurence Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephanie WangDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Emily ChangHIV, Infectious Diseases, and Global Medicine Division, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Patrick ByanyimaInfectious Diseases Research Collaboration, Kampala, Uganda.
Peter HuangDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Ingvar SanyuInfectious Diseases Research Collaboration, Kampala, Uganda.
Emmanuel MusisiInfectious Diseases Research Collaboration, Kampala, Uganda.
Abdul SessoloInfectious Diseases Research Collaboration, Kampala, Uganda.
J Lucian DavisEpidemiology of Microbial Diseases, Yale School of Public Health and Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
William WorodriaInfectious Diseases Research Collaboration, Kampala, Uganda.
Laurence HuangHIV, Infectious Diseases, and Global Medicine Division, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA. jue.lin@ucsf.edu.
Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study - Diversity SupplementR01HL128156 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE, HUNT, PETER W · 2015 to 2024
$7.1M
International HIV-associated Opportunistic Pneumonias (IHOP) StudyR01HL090335 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2007 to 2011
$4.0M
TB and Other Pulmonary Complications of AIDS Research Training ProgramD43TW009607 · FIC · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN, KATAMBA, ACHILLES · 2013 to 2022
$3.2M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
FIC NIH HHS D43 TW009607NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL090335NHLBI NIH HHS R01 HL128156
6 · The paper itself

Abstract

Prior studies in predominantly European (Caucasian) populations have discovered common genetic variants (single nucleotide polymorphisms, SNPs) associated with leukocyte telomere length (LTL), but whether these same variants affect LTL in non-Caucasian populations are largely unknown. We investigated whether six genetic variants previously associated with LTL (TERC (rs10936599), TERT (rs2736100), NAF1 (7675998), OBFC1 (rs9420907), ZNF208 (rs8105767), and RTEL1 (rs755017)) are correlated with telomere length (TL) in peripheral blood mononuclear cells (PBMCs) in a cohort of Africans living with and without HIV and undergoing evaluation for tuberculosis (TB). We found OBFC1 and the genetic sum score of the effect alleles across all six loci to be associated with shorter TL (adjusted for age, gender, HIV status, and smoking pack-years (p < 0.02 for both OBFC1 and the genetic sum score). In an analysis stratified by HIV status, the genetic sum score is associated with LTL in both groups with and without HIV. On the contrary, a stratified analysis according to TB status revealed that in the TB-positive subgroup, the genetic sum score is not associated with LTL, whereas the relationship remains in the TB-negative subgroup. The different impacts of HIV and TB on the association between the genetic sum score and LTL indicate different modes of modification and suggest that the results found in this cohort with HIV and TB participants may not be applied to the African general population. Future studies need to carefully consider these confounding factors.

Indexed as

AdultAfricaAllelesCohort StudiesDemographyDNA HelicasesFemaleGenome-Wide Association StudyHIV InfectionsHumansLeukocytesMalePolymorphism, Single NucleotideRibonucleoproteinsRNATelomeraseDNA HelicasesNAF1 protein, humanRibonucleoproteinsRNARTEL1 protein, humanStn1 protein, humanTelomerasetelomerase RNATelomere-Binding ProteinsTERT protein, human

Identifiers

PMID31388112
PMCPMC7039711

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.