ArticleScientific reports2019
Metabolomics-based biomarker discovery for bee health monitoring: A proof of concept study concerning nutritional stress in Bombus terrestris.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Non-Targeted and Targeted Screening of Organic Contaminants in Honeybees' Death Incidents in Greece: A Story Beyond Pesticides.Journal of xenobiotics · 2026Article
- How Environmental and Ecological Stressors Reprogram Honey Bee Chemistry Through the Microbiome-Metabolome Axis.Insects · 2026Review
- Leveraging Transcriptional Signatures of Diverse Stressors for Bumble Bee Conservation.Molecular ecology · 2025Article
- Proteome-metabolome profiling of wax gland complex reveals functional changes in honeybee,iScience · 2024Article
- A comprehensive metabolite fingerprint of fibrostenosis in patients with Crohn's disease.Scientific reports · 2023Article
- Using physiology to better support wild bee conservation.Conservation physiology · 2023Article
- Hemolymph Metabolism Analysis of Honey Bee (Insects · 2022Article
- Combined transcriptome and metabolite profiling analyses provide insights into the chronic toxicity of carbaryl and acetamiprid to Apis mellifera larvae.Scientific reports · 2022Article
- Application of the Metabolomics Approach in Food Authentication.Molecules (Basel, Switzerland) · 2021Review
- Methodology for Single Bee and Bee BrainMetabolites · 2021Article
- MappingFoods (Basel, Switzerland) · 2021Article
- Bacillus Subtilis 29784 as a Feed Additive for Broilers Shifts the Intestinal Microbial Composition and Supports the Production of Hypoxanthine and Nicotinic Acid.Animals : an open access journal from MDPI · 2021Article
- Article
- Improving bee health through genomics.Nature reviews. Genetics · 2020Review
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Authors and funding
6 authors.
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Abstract
Bee pollinators are exposed to multiple natural and anthropogenic stressors. Understanding the effects of a single stressor in the complex environmental context of antagonistic/synergistic interactions is critical to pollinator monitoring and may serve as early warning system before a pollination crisis. This study aimed to methodically improve the diagnosis of bee stressors using a simultaneous untargeted and targeted metabolomics-based approach. Analysis of 84 Bombus terrestris hemolymph samples found 8 metabolites retained as potential biomarkers that showed excellent discrimination for nutritional stress. In parallel, 8 significantly altered metabolites, as revealed by targeted profiling, were also assigned as candidate biomarkers. Furthermore, machine learning algorithms were applied to the above-described two biomarker sets, whereby the untargeted eight components showed the best classification performance with sensitivity and specificity up to 99% and 100%, respectively. Based on pathway and biochemistry analysis, we propose that gluconeogenesis contributed significantly to blood sugar stability in bumblebees maintained on a low carbohydrate diet. Taken together, this study demonstrates that metabolomics-based biomarker discovery holds promising potential for improving bee health monitoring and to identify stressor related to energy intake and other environmental stressors.
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