ArticleScientific reports2019
Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Insights into the Serum Metabolic Adaptations in Response to Inspiratory Muscle Training: A Metabolomic Approach Based onInternational journal of molecular sciences · 2023Trial
- Sex-Specific Plasma Metabolomic Signatures in COPD Reveal Creatine, Purine/Urate, and Bile-Acid Axes.Metabolites · 2026Article
- The Role of Tyrosine and C-Reactive Protein in COPD Exacerbations.Journal of clinical medicine · 2025Article
- Recommendations for sample selection, collection and preparation for NMR-based metabolomics studies of blood.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- The relationship between genetic prediction of 486 blood metabolites and the risk of COPD: mendelian randomization study.Scientific reports · 2025Article
- Serum metabolomics analysis of patients with chronic obstructive pulmonary disease and 'frequent exacerbator' phenotype.Molecular medicine reports · 2024Article
- Exploring the potential role of microbiota and metabolites in acute exacerbation of chronic obstructive pulmonary disease.Frontiers in microbiology · 2024Article
- Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers.Respiratory research · 2023Article
- Update on metabolomic findings in COPD patients.ERJ open research · 2023Review
- Changes in targeted metabolomics in lung tissue of chronic obstructive pulmonary disease.Journal of thoracic disease · 2023Article
- Metabolome Features of COPD: A Scoping Review.Metabolites · 2022Article
- Serum Levels of Acylcarnitines and Amino Acids Are Associated with Liberation from Organ Support in Patients with Septic Shock.Journal of clinical medicine · 2022Article
- Metabolomics Reveals Dysregulated Sphingolipid and Amino Acid Metabolism Associated with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- Metabolic Differences between Ex-Smokers and Nonsmokers: A Metabolomic Analysis.Journal of healthcare engineering · 2022Article
- U-Shape Relationship between Plasma Leucine Level and Mortality in the Intensive Care Unit.Disease markers · 2022Article
- Pharmacometabolomics identifies candidate predictor metabolites of an L-carnitine treatment mortality benefit in septic shock.Clinical and translational science · 2021Article
- Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD.Medicine and science in sports and exercise · 2021Article
- Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives.Frontiers in molecular biosciences · 2021Review
- Metabolic Fingerprinting Uncovers the Distinction Between the Phenotypes of Tuberculosis Associated COPD and Smoking-Induced COPD.Frontiers in medicine · 2021Article
- Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
24 authors at 14 institutions in 2 countries.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA. wlabaki@med.umich.edu.
Tian GuDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Susan MurrayDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5191-4847
Larisa YeomansBiochemical NMR Core and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
R Graham BarrDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY, USA.
Alejandro P ComellasDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa, Iowa City, IA, USA.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Christopher B CooperDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Igor BarjaktarevicDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Richard E KannerDivision of Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.
Robert PaineDivision of Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.
Merry-Lynn N McDonaldDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jerry A KrishnanDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL, USA.
Stephen P PetersSection on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, NC, USA.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
Wanda K O'NealMarsico Lung Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wenqi DiaoDepartment of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
Bei HeDepartment of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY, USA.
Theodore J StandifordDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Kathleen A StringerDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USPeking University · CNUniversity of California, Los Angeles · USUniversity of Utah · USColumbia University · USCornell University · USJohns Hopkins University · USNational Jewish Health · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USWake Forest University · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MPULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9MParametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0MDefining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2ML-Carnitine Pharmacometabolomics in Sepsis (CaPS)R01GM111400 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STRINGER, KATHLEEN A · 2016 to 2019
$1.2MNetwork Medicine Approaches to Cachexia in COPDR00HL121087 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2017 to 2019
$747kModulation of Steroid Suppression by Alveolar Macrophage EfferocytosisI01CX000911 · VA · VETERANS HEALTH ADMINISTRATION · PI CURTIS, JEFFREY LOUIS · 2016 to 2020
–CSRD VA I01 CX000911NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS R00 HL121087NHLBI NIH HHS R01 HL122438NHLBI NIH HHS T32 HL007749NHLBI NIH HHS U01 HL137880NIEHS NIH HHS P30 ES005605NIGMS NIH HHS R01 GM111400
Abstract
Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-smokers from the SPIROMICS cohort. We measured 27 serum metabolites, mostly amino acids, by
Indexed as
SmokersAmino AcidsFemaleHumansIsoleucineLeucineMaleMetabolomicsMiddle AgedPatient Outcome AssessmentProton Magnetic Resonance SpectroscopyPulmonary Disease, Chronic ObstructiveTryptophanValineAmino AcidsIsoleucineLeucineTryptophanValine
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LicenceCC BY
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.