ArticleScientific reports2019
The effects of spaceflight and fracture healing on distant skeletal sites.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Craniofacial Bones and Teeth in Spacefarers: Systematic Review and Meta-analysis.JDR clinical and translational research · 2023Pooled it
- Spaceflight and the rodent skeleton: A perspective.Bone reports · 2026Review
- A novel mineral-organic bone adhesive promotes calvarial bone regeneration in microgravity conditions.NPJ microgravity · 2026Article
- Article
- Review
- Microgravity's effects on miRNA-mRNA regulatory networks in a mouse model of segmental bone defects.PloS one · 2024Article
- Upregulation ofFrontiers in physiology · 2024Article
- Adequacy of in-mission training to treat tibial shaft fractures in mars analogue testing.Scientific reports · 2023Article
- Bone, fat, and muscle interactions in health and disease.Archives of endocrinology and metabolism · 2022Review
- Review
- Effects of diet, BMP-2 treatment, and femoral skeletal injury on endothelial cells derived from the ipsilateral and contralateral limbs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Systemic effects of BMP2 treatment of fractures on non-injured skeletal sites during spaceflight.Frontiers in endocrinology · 2022Article
- Bone health in spacefaring rodents and primates: systematic review and meta-analysis.NPJ microgravity · 2021Article
- Gravitational Influence on Human Living Systems and the Evolution of Species on Earth.Molecules (Basel, Switzerland) · 2021Review
- The Effect of Space Travel on Bone Metabolism: Considerations on Today's Major Challenges and Advances in Pharmacology.International journal of molecular sciences · 2021Review
- Gene-metabolite networks associated with impediment of bone fracture repair in spaceflight.Computational and structural biotechnology journal · 2021Article
- Gene-Metabolite Network Linked to Inhibited Bioenergetics in Association With Spaceflight-Induced Loss of Male Mouse Quadriceps Muscle.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation.Scientific reports · 2020Article
- Spaceflight-Induced Bone Tissue Changes that Affect Bone Quality and Increase Fracture Risk.Current osteoporosis reports · 2020Review
- Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Spaceflight results in reduced mechanical loading of the skeleton, which leads to dramatic bone loss. Low bone mass is associated with increased fracture risk, and this combination may compromise future, long-term, spaceflight missions. Here, we examined the systemic effects of spaceflight and fracture surgery/healing on several non-injured bones within the axial and appendicular skeleton. Forty C57BL/6, male mice were randomized into the following groups: (1) Sham surgery mice housed on the earth (Ground + Sham); (2) Femoral segmental bone defect surgery mice housed on the earth (Ground + Surgery); (3) Sham surgery mice housed in spaceflight (Flight + Sham); and (4) Femoral segmental bone defect surgery mice housed in spaceflight (Flight + Surgery). Mice were 9 weeks old at the time of launch and were euthanized approximately 4 weeks after launch. Micro-computed tomography (μCT) was used to evaluate standard bone parameters in the tibia, humerus, sternebra, vertebrae, ribs, calvarium, mandible, and incisor. One intriguing finding was that both spaceflight and surgery resulted in virtually identical losses in tibial trabecular bone volume fraction, BV/TV (24-28% reduction). Another important finding was that surgery markedly changed tibial cortical bone geometry. Understanding how spaceflight, surgery, and their combination impact non-injured bones will improve treatment strategies for astronauts and terrestrial humans alike.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.