Evidence map›Paper›PMID 31388018›Full record

ArticleNature communications2019

Structural basis for the target specificity of actin histidine methyltransferase SETD3.

Shaobo Dai, John R Horton, Clayton B Woodcock, Alex W Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9.Chembiochem : a European journal of chemical biology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.Protein science : a publication of the Protein Society · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Regulation of actin isoforms in cellular and developmental processes.Seminars in cell & developmental biology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shaobo DaiDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
John R HortonDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0001-9749-8068
Clayton B WoodcockDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Alex W WilkinsonDepartment of Biology, Stanford University, Stanford, CA, 94305, USA.
Xing ZhangDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Or GozaniDepartment of Biology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-1365-4463
Xiaodong ChengDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. xcheng5@mdanderson.org.ORCID http://orcid.org/0000-0002-6967-6362
The University of Texas MD Anderson Cancer Center · USStanford University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
Function of PHD Domain Proteins in Chromatin RegulationR01GM079641 · NIGMS · STANFORD UNIVERSITY · PI GOZANI, OR P. · 2007 to 2020
$4.5M
Histone Lysine deMethylation: Structures, Inhibitions and MechanismsR01GM114306 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHENG, XIAODONG · 2015 to 2018
$1.2M
Orbitrap Elite High-Resolution Mass Spectrometer for Proteomics and MetabolomicsS10OD012304 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HAWKE, DAVID H · 2013 to 2013
$877k
Regulation of Signaling by Histidine Protein MethylationR01GM133051 · NIGMS · STANFORD UNIVERSITY · PI GOZANI, OR P. · 2019 to 2020
$632k
NCI NIH HHS P30 CA016672NIGMS NIH HHS R01 GM079641NIGMS NIH HHS R01 GM114306NIGMS NIH HHS R01 GM133051NIH HHS S10 OD012304
6 · The paper itself

Abstract

SETD3 is an actin histidine-N

Indexed as

Catalytic DomainActinsCrystallography, X-RayHistidineHistone-Lysine N-MethyltransferaseHistone MethyltransferasesLysineMethylationRecombinant ProteinsSubstrate SpecificityActinsHistidineHistone-Lysine N-MethyltransferaseHistone MethyltransferasesLysineRecombinant ProteinsSETD3 protein, human

Identifiers

PMID31388018
PMCPMC6684798
OpenAlexW2965096892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.