ArticleNature communications2019
Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.
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The trial behind it
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Who cites it
134 citing papers in PubMed.
- A cell-free lipid sterosomal therapeutic enables bone regeneration via USP18-mediated noncanonical S1P signaling.Bioactive materials · 2026Article
- Alkylsuccinylated Bentonite-GelMA Hybrid Hydrogels for Enhanced Mechanics and Osteogenic Drug Delivery.ACS omega · 2026Article
- Article
- Combatting psoriasis with nanomedicine: gamma-amino butyric acid-chitosan nanoparticles as a targeted anti-psoriatic therapy.Inflammopharmacology · 2026Article
- A LDH-Based Supramolecular Photosensitizer-Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling.Bioactive materials · 2026Article
- Application of Colloid Material in Prevention and Control of Coal Spontaneous Combustion in Coal Mine.ACS omega · 2026Review
- Black phosphorus-loaded mineralized UV-responsive chitosan hydrogel for enhanced osteogenesis and antibacterial activity.Regenerative biomaterials · 2026Article
- Polyethylene Glycol (PEG)-Based Wet-Adhesive Absorbable Bone Wax for Osseous Hemostasis and Repair.International journal of molecular sciences · 2025Article
- Antibacterial bionanocomposite hydrogel based on hydroxyethyl cellulose, poly(vinyl alcohol), and montmorillonite clay as a scaffold for bone tissue engineering application.Scientific reports · 2025Article
- Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.Bioactive materials · 2025Article
- Harnessing marine-derived materials for therapeutics innovations: Advances in biomaterials from the ocean.Materials today. Bio · 2025Review
- Nano-assisted dynamically assembled hydrogels with strong tissue adhesion and proactive immunomodulation for bone defect repair.Bioactive materials · 2025Article
- Supramolecular drug-laden hydrogel based on structural tautomerization enhances drug delivery for rheumatoid arthritis treatment.Bioactive materials · 2025Article
- [Preparation of calcium phosphate nanoflowers and evaluation of their antioxidant and osteogenic induction capabilitiesZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- Two-dimensional nanomaterials for bone disease therapy: multifunctional platforms for regeneration, anti-infection and tumor ablation.Journal of nanobiotechnology · 2025Review
- Synthesis of Hydroxyapatite-Gelatin Composite Hydrogel for Bone Tissue Application.Gels (Basel, Switzerland) · 2025Article
- Inhibition and Rescue of Hyperglycemia-Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell-Derived Microvesicles for Chronic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.Nature communications · 2025Article
- Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling.Materials today. Bio · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Injectable hydrogels can fill irregular defects and promote in situ tissue regrowth and regeneration. The ability of directing stem cell differentiation in a three-dimensional microenvironment for bone regeneration remains a challenge. In this study, we successfully nanoengineer an interconnected microporous networked photocrosslinkable chitosan in situ-forming hydrogel by introducing two-dimensional nanoclay particles with intercalation chemistry. The presence of the nanosilicates increases the Young's modulus and stalls the degradation rate of the resulting hydrogels. We demonstrate that the reinforced hydrogels promote the proliferation as well as the attachment and induced the differentiation of encapsulated mesenchymal stem cells in vitro. Furthermore, we explore the effects of nanoengineered hydrogels in vivo with the critical-sized mouse calvarial defect model. Our results confirm that chitosan-montmorillonite hydrogels are able to recruit native cells and promote calvarial healing without delivery of additional therapeutic agents or stem cells, indicating their tissue engineering potential.
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