Observational studyNature communications2019
Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke.
Observational study in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04165616 (MECHANIST), which is not on this map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MECHANIST: Motor rECovery witH eArly imagiNg In STroke
Who cites it
75 citing papers in PubMed.
- Role of Contralesional Corticoreticulospinal Tract Compensation in Walking Function After Stroke.Brain and behavior · 2026Trial
- Electroacupuncture for Motor Recovery in Subacute Stroke: A Randomized Trial Exploring CReST-Related Modulation.Brain and behavior · 2026Trial
- Myoelectric interface training enables targeted reduction in abnormal muscle co-activation.Journal of neuroengineering and rehabilitation · 2022Trial
- A Novel Wearable Device for Motor Recovery of Hand Function in Chronic Stroke Survivors.Neurorehabilitation and neural repair · 2020Trial
- Post-Stroke Abnormal Synergies Are a Resultant Behavior of the Interplay of Weakness, Spasticity, and Environmental Demands.Neurorehabilitation and neural repair · 2026Review
- Disrupted bilateral co-ordination of soleus motor units during early subacute stroke rehabilitation.The Journal of physiology · 2026Article
- Genetic architecture of MRI-derived cervical spinal cord morphology reveals sensory-motor axis and systemic disease associations.Nature communications · 2026Article
- Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands.medRxiv : the preprint server for health sciences · 2026Article
- Disruption of the spinal cord-gut axis alters microbial dynamics and carbohydrate cross-feeding in the gut.Communications biology · 2026Article
- Extent of damage to descending output from cortex rather than to specific cortical regions drives the emergence of flexor synergy in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Automated Quantification of Movement Qualities in the Human Upper Extremity After Stroke Using a Wearable Robot.Research square · 2026Article
- Modulation of Forward Propulsion and Foot Dorsiflexion by Spinal and Muscular Stimulation During Human Stepping.Life (Basel, Switzerland) · 2026Article
- Mitochondrial-neuroimmune interfaces in post-stroke spasticity: from acute brain injury to chronic motor phenotypes.Frontiers in neuroscience · 2026Review
- Involvement of the reticulospinal tract in the pathogenesis of spasticity after stroke and spinal cord injury.Frontiers in neuroscience · 2026Review
- EEG-timed neuromuscular stimulation shapes ipsilateral TMS-evoked motor responses in humans.Clinical neurophysiology practice · 2026Article
- EMG-guided human-machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study.Journal of neuroengineering and rehabilitation · 2025Article
- Article
- Quantitative assessment of dynamic movement reveals deficits due to hemiparetic stroke.Journal of neuroengineering and rehabilitation · 2025Article
- Neuroengineering approaches assessing structural and functional changes of motor descending pathways in stroke.Progress in biomedical engineering (Bristol, England) · 2025Review
- CXCR3-mediated natural killer cell infiltration exacerbates white matter injury after intracerebral haemorrhage.Brain : a journal of neurology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.