Evidence map›Paper›PMID 31387997›Full record

ArticleNature communications2019

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B

Gerburg K Schwaerzer, Hema Kalyanaraman, Darren E Casteel, Nancy D Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M Schilling, Hemal H Patel and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  12. Mitochondrial NADNature cardiovascular research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Gerburg K SchwaerzerDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Hema KalyanaramanDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Darren E CasteelDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Nancy D DaltonDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Yusu GuDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Seunghoe LeeDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Shunhui ZhuangDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Nisreen WahwahDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Jan M SchillingDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, 92093, USA.
Hemal H PatelDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, 92093, USA.
Qian ZhangDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Ayako MakinoDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Dianna M MilewiczDivision of Medical Genetics and Cardiology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Kirk L PetersonDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Gerry R BossDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Renate B PilzDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. rpilz@ucsd.edu.ORCID http://orcid.org/0000-0003-4555-3541
University of California San Diego · USThe University of Texas Health Science Center at Houston · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
Mechanisms of vascular pathology from abnormal protein kinase G signalingR01HL132141 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PILZ, RENATE B · 2016 to 2025
$4.5M
NHLBI NIH HHS R01 HL132141NINDS NIH HHS P30 NS047101NINDS NIH HHS U01 NS058030
6 · The paper itself

Abstract

People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report that mice heterozygous for the mutation have a three-fold increase in basal protein kinase G (PKG) activity, and develop age-dependent aortic dilation. Prkg1

Indexed as

AcetylcysteineAnimalsAorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionCobamidesCyclic GMP-Dependent Protein Kinase Type IDisease Models, AnimalEchocardiographyFemaleFree Radical ScavengersGain of Function MutationGene Knock-In TechniquesHEK293 CellsHumansMaleAcetylcysteineCobamidescobinamideCyclic GMP-Dependent Protein Kinase Type IFree Radical ScavengersPRKG1 protein, humanPrkg1 protein, mouse

Identifiers

PMID31387997
PMCPMC6684604
OpenAlexW2965487606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.