Evidence map›Paper›PMID 31387988›Full record

ArticleNature communications2019

Inferring broken detailed balance in the absence of observable currents.

Ignacio A Martínez, Gili Bisker, Jordan M Horowitz, Juan M R Parrondo

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Identification and quantification of irreversibility in stochastic systems.Physical chemistry chemical physics : PCCP · 2026
    Review
  3. Article
  4. Article
  5. Stochastic thermodynamics for biological functions.Quantitative biology (Beijing, China) · 2025
    Review
  6. Article
  7. Review
  8. A local-global principle for nonequilibrium steady states.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. General theory for localizing the where and when of entropy production meets single-molecule experiments.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Milestoning estimators of dissipation in systems observed at a coarse resolution.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Eukaryotic gene regulation at equilibrium, or non?Current opinion in systems biology · 2022
    Article
  16. Article
  17. Broken detailed balance and entropy production in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Article
  19. Review
  20. Improved bounds on entropy production in living systems.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ignacio A MartínezDepartamento de Estructura de la Materia, Física Termica y Electronica and GISC, Universidad Complutense de Madrid, 28040, Madrid, Spain. iamartinez@ucm.es.ORCID http://orcid.org/0000-0002-0208-7790
Gili BiskerDepartment of Biomedical Engineering, Faculty of Engineering, Center for Physics and Chemistry of Living Systems, Center for Nanoscience and Nanotechnology, Center for Light-Matter Interaction, Tel Aviv University, Tel Aviv, 6997801, Israel. bisker@tauex.tau.ac.il.ORCID http://orcid.org/0000-0003-2592-7956
Jordan M HorowitzDepartment of Biophysics, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-9139-0811
Juan M R ParrondoDepartamento de Estructura de la Materia, Física Termica y Electronica and GISC, Universidad Complutense de Madrid, 28040, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying dissipation is essential for understanding the physical mechanisms underlying nonequilibrium processes. In living systems, for example, the dissipation is directly related to the hydrolysis of fuel molecules such as adenosine triphosphate (ATP). Nevertheless, detecting broken time-reversal symmetry, which is the hallmark of dissipative processes, remains a challenge in the absence of observable directed motion, flows, or fluxes. Furthermore, quantifying the entropy production in a complex system requires detailed information about its dynamics and internal degrees of freedom. Here we introduce a novel approach to detect time irreversibility and estimate the entropy production from time-series measurements, even in the absence of observable currents. We apply our technique to two different physical systems, namely, a partially hidden network and a molecular motor. Our method does not require complete information about the system dynamics and thus provides a new tool for studying nonequilibrium phenomena.

Indexed as

EntropyModels, BiologicalAdenosine TriphosphateComputer SimulationHydrolysisTime FactorsAdenosine Triphosphate

Identifiers

PMID31387988
PMCPMC6684597

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.