Evidence map›Paper›PMID 31387976›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Structure, function, and ion-binding properties of a K

Cholpon Tilegenova, D Marien Cortes, Nermina Jahovic, Emily Hardy, Parameswaran Hariharan, Lan Guan, Luis G Cuello

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Do selectivity filter carbonyls in KJournal of structural biology: X · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Conductance selectivity of NaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Article
  14. Article
  15. TOK channels use the two gates in classical KFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  16. Selectivity filter modalities and rapid inactivation of the hERG1 channel.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cholpon TilegenovaCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430.
D Marien CortesCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430.
Nermina JahovicCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430.
Emily HardyCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430.
Parameswaran HariharanCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430.
Lan GuanCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430.ORCID 0000-0002-2274-361X
Luis G CuelloCell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430; luis.cuello@ttuhsc.edu.ORCID 0000-0001-5192-7568

Funding

High-resolution crystallographic and functional studies of K+ channel gatingR01GM097159 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI CUELLO, LUIS GONZALO · 2012 to 2021
$2.7M
Integrated approaches to symport mechanisms of membrane transportersR01GM122759 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GUAN, LAN · 2018 to 2021
$1.4M
Recombinant expression and functional characterization of a lysophosphatidylcholine transporterR21NS105863 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GUAN, LAN · 2018 to 2019
$421k
NIGMS NIH HHS R01 GM097159NIGMS NIH HHS R01 GM122759NINDS NIH HHS R21 NS105863
6 · The paper itself

Abstract

Here, we present the atomic resolution crystallographic structure, the function, and the ion-binding properties of the KcsA mutants, G77A and G77C, that stabilize the 2,4-ion-bound configuration (i.e., water, K

Indexed as

Bacterial ProteinsCell Membrane PermeabilityCrystallography, X-RayIon Channel GatingIonsModels, MolecularMutant ProteinsPotassium ChannelsProtein ConformationProtein StabilityBacterial ProteinsIonsMutant ProteinsPotassium Channelsprokaryotic potassium channelion permeationion selectivityKcsApotassium channelsselectivity filter

Identifiers

PMID31387976
PMCPMC6708363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.