Evidence map›Paper›PMID 31387948›Full record

ArticleThe Journal of biological chemistry2019

Inhibition of the ULK1 protein complex suppresses

Ohood A Radhi, Scott Davidson, Fiona Scott, Run X Zeng, D Heulyn Jones, Nicholas C O Tomkinson, Jun Yu, Edmond Y W Chan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Autophagy · 2025
    Article
  3. Review
  4. Review
  5. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ohood A RadhiStrathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom.
Scott DavidsonStrathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom.
Fiona ScottWestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1-1XL, Scotland, United Kingdom.
Run X ZengDepartment of Biomedical and Medical Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.
D Heulyn JonesWestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1-1XL, Scotland, United Kingdom.
Nicholas C O TomkinsonWestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1-1XL, Scotland, United Kingdom.
Jun YuStrathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom.
Edmond Y W ChanStrathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom eywc@queensu.ca.
University of Strathclyde · GBQueen's University · CA

Funding

Cancer Research UK
6 · The paper itself

Abstract

Autophagy plays multiple roles in host cells challenged with extracellular pathogens. Here, we aimed to explore whether autophagy inhibition could prevent bacterial infections. We first confirmed widely distinct patterns of autophagy responses in host cells infected with

Indexed as

AutophagyAutophagosomesAutophagy-Related Protein-1 HomologAutophagy-Related ProteinsCell DeathCytoplasmEnzyme InhibitorsHEK293 CellsHeLa CellsHumansIntracellular Signaling Peptides and ProteinsLysosomesSalmonellaStaphylococcusATG13 protein, humanAutophagy-Related Protein-1 HomologAutophagy-Related ProteinsEnzyme InhibitorsIntracellular Signaling Peptides and ProteinsULK1 protein, humanautophagyautophagy-related protein 13 (ATG13)bacterial pathogenesisbacterial virulenceinfectionintracellular pathogenSalmonella entericaStaphylococcus aureus (S. aureus)Unc-51-like autophagy-activating kinase 1 (ULK1)xenophagy

Identifiers

PMID31387948
PMCPMC6768650
OpenAlexW2964892149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.