Evidence map›Paper›PMID 31387906›Full record

ArticlemBio2019

Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus.

Paola K Párraga Solórzano, Jiangwei Yao, Charles O Rock, Thomas E Kehl-Fie

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Phosphate sensing by PhoPR regulates the cytotoxicity ofMicrobiology (Reading, England) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Effect of Ferredoxin Receptor FusA on the Virulence Mechanism ofFrontiers in cellular and infection microbiology · 2022
    Article
  10. Battle for Metals: Regulatory RNAs at the Front Line.Frontiers in cellular and infection microbiology · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Paola K Párraga SolórzanoDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0003-0710-5414
Jiangwei YaoDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0001-7088-3468
Charles O RockDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0001-8648-4189
Thomas E Kehl-FieDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA kehlfie@illinois.edu.ORCID 0000-0001-8234-1113
St. Jude Children's Research Hospital · USUniversidad de las Fuerzas Armadas ESPE · ECUniversity of Illinois Urbana-Champaign · US

Funding

REGULATION OF LIPID METABOLISM IN E COLIR01GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 1985 to 2022
$9.2M
REGULATION OF LIPID METABOLISM IN BACTERIAR37GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 2001 to 2010
$5.7M
Overcoming nutritional immunity: Staphylococcal adaptation to host-imposed manganese and zinc starvationR01AI118880 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2016 to 2020
$1.9M
Adaptation of Staphylococcus aureus to Mn and Zn starvation imposed by the hostK22AI104805 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2014 to 2015
$264k
NIAID NIH HHS K22 AI104805NIAID NIH HHS R01 AI118880NIGMS NIH HHS R01 GM034496NIGMS NIH HHS R37 GM034496
6 · The paper itself

Abstract

During infection, bacteria use two-component signal transduction systems to sense and adapt to the dynamic host environment. Despite critically contributing to infection, the activating signals of most of these regulators remain unknown. This also applies to the

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialGlycolysisHumansLeukocyte L1 Antigen ComplexManganeseProtein KinasesStaphylococcal InfectionsStaphylococcus aureusVirulenceArlR protein, Staphylococcus aureusArlS protein, Staphylococcus aureusBacterial ProteinsLeukocyte L1 Antigen ComplexManganeseProtein KinasesArlRScalprotectinglycolysismanganesenutritional immunityStaphylococcus aureus

Identifiers

PMID31387906
PMCPMC6686040
OpenAlexW2966762438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.