Evidence map›Paper›PMID 31387875›Full record

ArticleeNeuro

Transcriptomic Signatures of Postnatal and Adult Intrinsically Photosensitive Ganglion Cells.

Daniel J Berg, Katherine Kartheiser, Megan Leyrer, Alexandra Saali, David M Berson

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  9. A newbioRxiv : the preprint server for biology · 2024
    Article
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  12. Article
  13. Photic Entrainment of the Circadian System.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel J BergMolecular Biology, Cellular Biology, and Biochemistry Program, Brown University, Providence, Rhode Island 02912 David_berson@brown.edu Daniel_berg@alumni.brown.edu.ORCID 0000-0002-3176-5423
Katherine KartheiserDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912.
Megan LeyrerDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912.
Alexandra SaaliDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912.
David M BersonDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912 David_berson@brown.edu Daniel_berg@alumni.brown.edu.
John Brown University · US

Funding

STRUCTURE AND FUNCTION OF MAMMALIAN GANGLION CELLSR01EY012793 · NEI · BROWN UNIVERSITY · PI BERSON, DAVID M. · 2000 to 2022
$9.3M
NEI NIH HHS R01 EY012793
6 · The paper itself

Abstract

Intrinsically photosensitive retinal ganglion cells (ipRGCs) are rare mammalian photoreceptors essential for non-image-forming vision functions, such as circadian photoentrainment and the pupillary light reflex. They comprise multiple subtypes distinguishable by morphology, physiology, projections, and levels of expression of melanopsin (Opn4), their photopigment. The molecular programs that distinguish ipRGCs from other ganglion cells and ipRGC subtypes from one another remain elusive. Here, we present comprehensive gene expression profiles of early postnatal and adult mouse ipRGCs purified from two lines of reporter mice that mark different sets of ipRGC subtypes. We find dozens of novel genes highly enriched in ipRGCs. We reveal that

Indexed as

TranscriptomeAnimalsCircadian RhythmFemaleGene Expression ProfilingGuanine Nucleotide Exchange FactorsMaleMice, TransgenicRetinal Ganglion CellsT-Box Domain ProteinsGuanine Nucleotide Exchange FactorsRasgrp1 protein, mouseT-Box Domain ProteinsTbx20 protein, mousecell typecircadianintrinsically photosensitiveretinal ganglionRNA-seqvision

Identifiers

PMID31387875
PMCPMC6712207
OpenAlexW2964775026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.