Evidence map›Paper›PMID 31387868›Full record

Trial reportPediatrics2019

A Pivotal Response Treatment Package for Children With Autism Spectrum Disorder: An RCT.

Grace W Gengoux, Daniel A Abrams, Rachel Schuck, Maria Estefania Millan, Robin Libove, Christina M Ardel, Jennifer M Phillips, Melanie Fox, Thomas W Frazier, Antonio Y Hardan

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02037022 (Pivotal Response Treatment Package for Young Children With Autism), which is not on this map. Cited by 54 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02037022 nacompletednot on this map

Pivotal Response Treatment Package for Young Children With Autism

TypeinterventionalSponsorStanford UniversityRan2013 to 2017Enrolled48ConditionsAutism Spectrum Disorder (ASD), AutismArmsPivotal Response Treatment Package (PRT-P)
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Grace W GengouxDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California; ggengoux@stanford.edu.
Daniel A AbramsDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.
Rachel SchuckDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.
Maria Estefania MillanDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.
Robin LiboveDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.
Christina M ArdelDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.
Jennifer M PhillipsDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.
Melanie FoxPGSP - Stanford Psy.D. Consortium, Palo Alto University, Palo Alto, California; and.
Thomas W FrazierAutism Speaks, New York, New York.
Antonio Y HardanDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California.

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Decoding Neural Systems Underlying Affective Prosody in Children with AutismK01MH102428 · NIMH · STANFORD UNIVERSITY · PI ABRAMS, DANIEL ARTHUR · 2014 to 2016
$525k
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NIMH NIH HHS K01 MH102428
6 · The paper itself

Abstract

objectivesOur aim was to conduct a randomized controlled trial to evaluate a pivotal response treatment package (PRT-P) consisting of parent training and clinician-delivered in-home intervention on the communication skills of children with autism spectrum disorder.

methodsForty-eight children with autism spectrum disorder and significant language delay between 2 and 5 years old were randomly assigned to PRT-P (

resultsAnalysis of child utterances during the structured laboratory observation revealed that, compared with the delayed treatment group, children in PRT-P demonstrated greater improvement in frequency of functional utterances (F

conclusionsThis is the first 24-week randomized controlled trial in which community treatment is compared with the combination of parent training and clinician-delivered PRT. PRT-P was effective for improving child social communication skills and for teaching parents to implement PRT. Additional research will be needed to understand the optimal combination of treatment settings, intensity, and duration, and to identify child and parent characteristics associated with treatment response.

Indexed as

CommunicationHome Care ServicesParent-Child RelationsAutism Spectrum DisorderBehavior TherapyChild, PreschoolCombined Modality TherapyFemaleHumansMaleParents

Identifiers

PMID31387868
PMCPMC6856784

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.